Phl(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones

被引：70

作者：

Liu, Le ^{[1
]}

Lu, Hang ^{[1
]}

Wang, Hong ^{[1
]}

Yang, Chao ^{[1
]}

Zhang, Xiang ^{[1
]}

Zhang-Negrerie, Daisy ^{[1
]}

Du, Yunfei ^{[1
]}

Zhao, Kang ^{[1
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 12期

基金：

中国国家自然科学基金;

关键词：

ELECTROCYCLIC RING-CLOSURE; EFFICIENT SYNTHESIS; OXIDATIVE REARRANGEMENTS; DIRECT ALKYNYLATION; DIRECT ARYLATIONS; ALKENES; CYCLIZATION; FACILE; CRYPTOSANGUINOLENTINE; AMINOACETOXYLATION;

D O I：

10.1021/ol400743r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of the readily available N-methyl-N-phenylcinnamamides with phenyliodine bis(trifluoroacetate) (PIFA) In the presence of Lewis acids provides a general and efficient assembly of a variety of 3-arylquinolin-2-one compounds. This novel approach features not only metal-free oxidative C(sp(2))-C(sp(2)) bond formation but also an exclusive 1,2-aryl migration.

引用

页码：2906 / 2909

页数：4

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