Retrospective analysis of Pulmonary Surfactant on Respiratory Distress Syndrome of Late Premature or Full-term Infants Paper Title

This retrospective analysis evaluates the effcacy of pulmonary surfactant in respiratory distress syndrome treatment of late premature or trem infants. We compared infants receiving Curosurf pig pulmonary surfactant (PS group n=89) with those infants who didn't (control group n=77). Both were treated with routine treatment and mechanical ventilation. The highest oxygenation indexes in PS group were obviously higher than those in control group (P<0.001), The time of hospital stay, Mechanical ventilation and CPAP, the incidence of Ventilator-associated pneumonia and hospitalization expenses of PS group were obviously higher than that in control group(P<0.05). There were no significant differences about NO inhalation, the incidence of pulmonar>0.05). PS should be applied for late premature and full-term RDS patients in the early stage, and clinical studies on PS treatment of late premature infants or full-term infants for the best medication time and optimal dosage should be further explored.