Management of penoscrotal extramammary Paget disease: case series and review of the literature

被引：29

作者：

Moretto, P. ^{[1
]}

Nair, V. J. ^{[2
]}

El Hallani, S. ^{[3
]}

Malone, S. ^{[2
]}

Belanger, E. ^{[3
]}

Morash, C. ^{[4
]}

Canil, C. M. ^{[1
]}

机构：

[1] Univ Ottawa, Dept Med, Ottawa Hosp Canc Ctr, Div Med Oncol,Dept Med,Ottawa Hosp Res Inst, Ottawa, ON, Canada

[2] Univ Ottawa, Ottawa Hosp Canc Ctr, Ottawa Hosp Res Inst, Div Radiat Oncol,Dept Radiol, Ottawa, ON, Canada

[3] Univ Ottawa, Ottawa Hosp, Dept Pathol & Lab Med, Div Anat Pathol, Ottawa, ON, Canada

[4] Univ Ottawa, Ottawa Hosp Res Inst, Ottawa Hosp Canc Ctr, Div Urol, Ottawa, ON, Canada

来源：

CURRENT ONCOLOGY | 2013年 / 20卷 / 04期

关键词：

Extramammary Paget disease; apocrine carcinoma; case series; treatment; pathology; COMBINATION CHEMOTHERAPY; RADIOTHERAPY; SCROTUM; VULVA; ADENOCARCINOMA; PACLITAXEL; DOCETAXEL; ESTROGEN; FEATURES; THERAPY;

D O I：

10.3747/co.20.1353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extramammary Paget disease (EMPD) is a rare, slow-growing neoplasm, considered to be an adenocarcinoma of the apocrine glands. In men, the penoscrotal region is the most commonly affected area. The disease can present as carcinoma in situ or as invasive disease that can subsequently metastasize to lymph nodes and distant sites. Because of the rarity of empd, the medical literature available to guide management of the disease is limited, particularly in patients with metastases. In addition, metastatic disease may pose a diagnostic challenge, because invasive cancer of the genitourinary or gastrointestinal tract can occur in association with empd. In the present case series, we describe our experience in treating penoscrotal empd with multimodality therapy, and we review the existing literature concerning its diagnosis and management.

引用

页码：E311 / E320

页数：10

共 73 条

[1]

[Anonymous], 1893, ANN DERMATOL SYPHIL

[2] METASTATIC EXTRAMAMMARY PAGETS-DISEASE - DRAMATIC RESPONSE TO COMBINED MODALITY TREATMENT [J].