Supramolecular Control of Selectivity in Hydroformylation of Vinyl Arenes: Easy Access to Valuable β-Aldehyde Intermediates

被引：63

作者：

Dydio, Pawel ^{[1
]}

Reek, Joost N. H. ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 14期

关键词：

hydroformylation; P ligands; rhodium; supramolecular chemistry; transition metals; REGIOSELECTIVE HYDROFORMYLATION; TETRAPHOSPHORUS LIGANDS; HYDROGEN-BOND; DERIVATIVES; ALCOHOLS; CATALYST; OLEFINS; ISOMERIZATION; EPOXIDATION; ACTIVATION;

D O I：

10.1002/anie.201209582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand-substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3878 / 3882

页数：5

共 49 条

[1] Olefin insertion into the rhodium-hydrogen bond as the step determining the regioselectivity of rhodium-catalyzed hydroformylation of vinyl substrates: Comparison between theoretical and experimental results [J].