Distinctive diffusion-weighted imaging features in late-onset genetic leukoencephalopathies

被引：5

作者：

De Cocker, Laurens J. L. ^{[1
]}

Castillo, Mauricio ^{[2
]}

机构：

[1] AZ Maria Middelares, Dept Radiol, Buitenring Sint Denijs 30, B-9000 Ghent, Belgium

[2] Univ N Carolina, Sch Med, Dept Radiol, Chapel Hill, NC 27515 USA

来源：

NEURORADIOLOGY | 2021年 / 63卷 / 01期

关键词：

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP); Fragile X-associated tremor and; or ataxia syndrome (FXTAS); Neuronal intranuclear inclusion disease (NIID); Leukoencephalopathy due to autosomal recessive mutations in the mitochondrial alanyl-transfer RNA (tRNA) synthetase gene (AARS2-L);

D O I：

10.1007/s00234-020-02543-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic leukoencephalopathies are inherited disorders characterized by progressive white matter involvement. Although most are paediatric conditions, late-onset adult leukoencephalopathies are being increasingly recognized. Adult leukoencephalopathies may present as neurodegenerative diseases with cognitive decline and motor symptoms. Similar to their paediatric counterparts, different adult leukoencephalopathies often have distinctive MRI appearances. In particular, DWI has been recently shown to demonstrate specific patterns of persistent diffusion restriction in several adult-onset leukoencephalopathies. As such, DWI may provide important clues to the diagnosis of adult-onset leukoencephalopathy. The purpose of this review is to discuss characteristic DWI features in some late-onset leukoencephalopathies.

引用

页码：153 / 156

页数：4

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