Biobanking for research in surgery: are surgeons in charge for advancing translational research or mere assistants in biomaterial and data preservation?
Translational research;
Biobanking;
Tissue banking;
Pre-analytics;
Informed consent;
Biobank governance;
HUMAN HEPATOCYTES;
PROTEIN EXPRESSION;
PROTEOMIC ANALYSIS;
EMBEDDED TISSUES;
CANCER TISSUE;
PURIFICATION;
EXTRACTION;
ETHICS;
CELLS;
LEGAL;
D O I:
10.1007/s00423-013-1060-y
中图分类号:
R61 [外科手术学];
学科分类号:
摘要:
High-quality biospecimens of human origin with annotated clinical and procedural data are an important tool for biomedical research, not only to map physiology, pathophysiology and aetiology but also to go beyond in translational research. This has opened a new special field of research known as 'biobanking', which focuses on how to collect, store and provide these specimens and data, and which is substantially supported by national and European funding. An overview on biobanking is given, with a closer look on a clinical setting, concerning a necessary distinction from clinical trials and studies as well as a comparison of prospective sample collection with secondary use of archived samples from diagnostics. Based on a summary of possible use and scientific impact of human tissue in research, it is shown how surgical expertise boosts the scientific value of specimens and data. Finally, an assessment of legal and ethical issues especially from a surgical perspective is given, followed by a model of interdisciplinary biobanking within a joint 'centre' that as synergistic structure merges essential input from surgery as well as laboratory medicine, pathology and biometry. Within the domain of biobanking, surgeons have to develop a better awareness of their role within translational research, not only on the level of medical faculties but also as nationally and internationally funded initiatives. Therefore, the authors suggest a platform for biobanking within the German association of surgeons in analogy to the existing special interest group for clinical trials.
机构:
Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USAUniv Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
Behne, Tara
Copur, M. Sitki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
St Francis Canc Treatment Ctr, Grand Isl, NE 68803 USAUniv Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
机构:
Translat Res Ctr, London, ON, Canada
Childrens Hlth Res Inst, London, ON, CanadaTranslat Res Ctr, London, ON, Canada
Brisson, Alayne R.
Matsui, Doreen
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, CanadaTranslat Res Ctr, London, ON, Canada
Matsui, Doreen
Rieder, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaTranslat Res Ctr, London, ON, Canada
Rieder, Michael J.
Fraser, Douglas D.
论文数: 0引用数: 0
h-index: 0
机构:
Translat Res Ctr, London, ON, Canada
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada
Ctr Crit Illness Res, London, ON, CanadaTranslat Res Ctr, London, ON, Canada
机构:
Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USAUniv Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
Behne, Tara
Copur, M. Sitki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
St Francis Canc Treatment Ctr, Grand Isl, NE 68803 USAUniv Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA
机构:
Translat Res Ctr, London, ON, Canada
Childrens Hlth Res Inst, London, ON, CanadaTranslat Res Ctr, London, ON, Canada
Brisson, Alayne R.
Matsui, Doreen
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, CanadaTranslat Res Ctr, London, ON, Canada
Matsui, Doreen
Rieder, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, CanadaTranslat Res Ctr, London, ON, Canada
Rieder, Michael J.
Fraser, Douglas D.
论文数: 0引用数: 0
h-index: 0
机构:
Translat Res Ctr, London, ON, Canada
Childrens Hlth Res Inst, London, ON, Canada
Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada
Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada
Ctr Crit Illness Res, London, ON, CanadaTranslat Res Ctr, London, ON, Canada