Reference values for leptin/adiponectin ratio in healthy children and adolescents

被引：17

作者：

Lausten-Thomsen, Ulrik ^{[1
,2
]}

Lund, Morten Asp Vonsild ^{[2
,3
]}

Frithioff-Bojsoe, Christine ^{[2
,4
]}

Hedley, Paula Louise ^{[5
]}

Pedersen, Oluf ^{[4
]}

Hansen, Torben ^{[4
]}

Christiansen, Michael ^{[3
,5
]}

Holm, Jens-Christian ^{[2
,4
,6
]}

机构：

[1] Copenhagen Univ Hosp, Dept Neonatol, Rigshosp, Copenhagen, Denmark

[2] Copenhagen Univ Hosp Holbaek, Dept Pediat, Childrens Obes Clin, Holbaek, Denmark

[3] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark

[4] Univ Copenhagen, Novo Nord Fdn, Ctr Basic Metab Res, Copenhagen, Denmark

[5] Statens Serum Inst, Dept Congenital Disorders, Danish Natl Biobank & Biomarkers, Copenhagen, Denmark

[6] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark

来源：

CLINICA CHIMICA ACTA | 2019年 / 493卷

关键词：

Adipokines; Adiponectin; Biomarkers; Children; Leptin; Reference values; MOLECULAR-WEIGHT ADIPONECTIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; NONOBESE CHILDREN; SERUM LEPTIN; INDEX; HOMEOSTASIS; PUBERTY; CANCER; RISK;

D O I：

10.1016/j.cca.2019.03.004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios. Methods: Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits. Results: Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p <.001). Conclusion: The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.

引用

页码：123 / 128

页数：6

共 45 条

[1] Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary [J].