The antioxidant system in the soleus muscle of growing rats is stimulated by the administration of a low-protein/high-carbohydrate diet

被引：1

作者：

Silvino da Silva, Flavia Hosaki ^{[1
]}

dos Santos, Maisa Pavani ^{[1
]}

Pereira, Mayara Peron ^{[1
]}

Buzelle, Samyra Lopes ^{[2
]}

Allebrandt Neto, Edgar Wilibaldo ^{[1
]}

Gai, Bibiana Mozzaquatro ^{[1
]}

Correia, Francyele dos Santos ^{[1
]}

Alves, Cristina Helena ^{[1
]}

de Franca, Suelem Aparecida ^{[1
]}

Kawashita, Nair Honda ^{[1
]}

机构：

[1] Univ Fed Mato Grosso, Dept Chem, Cuiaba, MG, Brazil

[2] Univag Univ Ctr Varzea Grande, Htlh Sci Area, Varzea Grande, MG, Brazil

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2019年 / 125卷 / 03期

关键词：

Low-protein high-carbohydrate diet; oxidative stress; skeletal muscle; antioxidant enzymes; xanthine oxidase; SKELETAL-MUSCLE; OXIDATIVE STRESS; OXIDIZED PROTEINS; XANTHINE-OXIDASE; PROTEASOME; UNDERNUTRITION; DEGRADATION; NUTRITION; CASPASE-3; ATROPHY;

D O I：

10.1080/13813455.2018.1455709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to evaluate the generation of reactive oxygen species (ROS) by xanthine oxidase (XO), the enzymatic antioxidant system and oxidative damage in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity by 45% and the activities of glutathione peroxidase (GPx), glutathione reductase and catalase in the soleus muscles. There was an increase in the carbonylated proteins with no increase thiobarbituric acid reactive substances (TBARS), although the XO activity had increased 20%. In EDL muscles, the LPHC diet increased XO activity by 66% and the TBARS levels by 80%, and only GPx had its activity increased. These results suggest that the enzymatic antioxidant system of the soleus muscle has a better response to the increase of ROS production stimulated by LPHC diet.

引用

页码：276 / 283

页数：8

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