Blockade of CD47 or SIRPα: a new cancer immunotherapy

被引：14

作者：

Murata, Yoji ^{[1
]}

Saito, Yasuyuki ^{[1
]}

Kotani, Takenori ^{[1
]}

Matozaki, Takashi ^{[1
]}

机构：

[1] Kobe Univ, Div Mol & Cellular Signaling, Dept Biochem & Mol Biol, Grad Sch Med, Kobe, Hyogo 6500017, Japan

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2020年 / 24卷 / 10期

基金：

日本学术振兴会;

关键词：

Cancer; CD47; immunotherapy; macrophage; phagocytosis; SIRP alpha; PHAGOCYTOSIS; CHECKPOINT; SELF;

D O I：

10.1080/14728222.2020.1811855

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The CD47-Signal regulatory protein alpha (SIRP alpha) singling axis acts as a crucial regulator that limits the phagocytic activity of professional phagocytes such as macrophages. Recent studies have demonstrated that the interaction between CD47 on tumor cells and SIRP alpha on macrophages is implicated in the ability of tumors to evade immunosurveillance. Targeting the CD47-SIRP alpha interaction is therefore considered to be a promising approach for cancer therapy. Herein, we review some of studies displaying the potential clinical application of antibodies and other modalities that target the CD47-SIRP alpha interaction. Current limitations of the CD47-SIRP alpha-targeted immunotherapeutic approaches are also discussed as well as other avenues for future study to improve the current strategies in targeting the CD47-SIRP alpha signaling axis for cancer immunotherapy.

引用

页码：945 / 951

页数：7

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