Synthesis, screening and antimicrobial activity evaluation of spiro indolothiazolidinone, oxazolidinone and azetidene derivatives of benzenesulfonyl chloride

被引：2

作者：

Deokar, Hrushikesh ^{[1
]}

Chaskar, Jyotsna ^{[2
]}

Chaskar, Atul ^{[1
,3
]}

机构：

[1] CK Thakur Res Ctr, Navi Mumbai 410206, India

[2] CK Thakur Coll, Dept Biotechnol, Navi Mumbai 410206, India

[3] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 46卷 / 07期

关键词：

Indolothiazolidinone; oxazolidinone; azetidene; antimicrobial activity; MAMMALIAN-CELL CYCLE; CATALYTIC ASYMMETRIC-SYNTHESIS; ASPERGILLUS-FUMIGATUS; INHIBITORS; FACILE;

D O I：

10.1007/s11094-012-0814-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an attempt to find a new class of antimicrobial agents, a series of indolothiazolidinone, oxazolidinone, and azetidene analogs of benzenesulfonyl chloride have been synthesized and evaluated for their antibacterial activity against S. aureus, S. typhi and E. coli, expressed as the minimum inhibitory concentration (MIC50,mu g/mL). Some of the synthesized compounds (4a-4d, 5a- 5d, and 6a-6d) exhibit promising antibacterial activity that is attributed to their spiro structure.

引用

页码：429 / 434

页数：6

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