Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats

被引：44

作者：

Bernardi, Caren ^{[1
]}

Tramontina, Ana Carolina ^{[2
]}

Nardin, Patricia ^{[2
]}

Biasibetti, Regina ^{[2
]}

Costa, Ana Paula ^{[2
]}

Vizueti, Adriana Fernanda ^{[2
]}

Batassini, Cristiane ^{[2
]}

Tortorelli, Lucas Silva ^{[2
]}

Wartchow, Krista Mineia ^{[2
]}

Dutra, Marcio Ferreira ^{[2
]}

Bobermin, Larissa ^{[2
]}

Sesterheim, Patricia ^{[2
]}

Quincozes-Santos, Andre ^{[2
]}

de Souza, Jaqueline ^{[2
]}

Goncalves, Carlos Alberto ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Neurociencias, BR-90046900 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil

来源：

NEURAL PLASTICITY | 2013年 / 2013卷

关键词：

FIBRILLARY ACIDIC PROTEIN; LONG-TERM POTENTIATION; NEUROTROPHIC FACTOR; METHODOLOGICAL FEATURES; GLUTAMINE-SYNTHETASE; MODERATE EXERCISE; BRAIN HEALTH; BDNF; MEMORY; METABOLISM;

D O I：

10.1155/2013/709732

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physical exercise effects on brain health and cognitive performance have been described. Synaptic remodeling in hippocampus induced by physical exercise has been described in animal models, but the underlying mechanisms remain poorly understood. Changes in astrocytes, the glial cells involved in synaptic remodeling, need more characterization. We investigated the effect of moderate treadmill exercise (20 min/day) for 4 weeks on some parameters of astrocytic activity in rat hippocampal slices, namely, glial fibrillary acidic protein (GFAP), glutamate uptake and glutamine synthetase (GS) activities, glutathione content, and S100B protein content and secretion, as well as brain-derived neurotrophic factor (BDNF) levels and glucose uptake activity in this tissue. Results show that moderate treadmill exercise was able to induce a decrease in GFAP content (evaluated by ELISA and immunohistochemistry) and an increase in GS activity. These changes could be mediated by corticosterone, whose levels were elevated in serum. BDNF, another putative mediator, was not altered in hippocampal tissue. Moreover, treadmill exercise caused a decrease in NO content. Our data indicate specific changes in astrocyte markers induced by physical exercise, the importance of studying astrocytes for understanding brain plasticity, as well as reinforce the relevance of physical exercise as a neuroprotective strategy.

引用

页数：10

共 72 条

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