Factor V Leiden, prothrombin G20210A and protein C mutation frequency in Turkish venous thrombosis patients

被引:16
作者
Altinisik, Julide [1 ]
Ates, Omer [1 ]
Ulutin, Turgut [1 ]
Cengiz, Mujgan [1 ]
Buyru, Nur [1 ]
机构
[1] Istanbul Univ, Dept Med Biol, Cerrahpasa Med Fac, Istanbul, Turkey
关键词
factor V Leiden; protein C; prothrombin; venous thrombosis; coagulation factors;
D O I
10.1177/1076029607306404
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Several inherited polymorphisms are associated with risk of venous thrombosis, including Mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene. In this study, genotyping for factor V, prothrombin, and protein C Mutations was performed in 50 patients and 25 control Subjects by polymerase chain reaction-based analysis. The prevalence of factor V and prothrombin mutations was not significantly different from that in the general population. Nine Of the patients had heterozygous protein C mutation. There was a high prevalence of the Mutated protein C allele in the Pulmonary emboli group (42.8%). Protein C mutation incidence was higher in the pulmonary emboli group than in the deep vein thrombosis (8.33%) and cerebral vein thrombosis (16.1%) groups. These results indicate that patients with protein C deficiency have a greater risk of thrombosis than patients with factor V or prothrombin G20210A mutation.
引用
收藏
页码:415 / 420
页数:6
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