Defining the Role of Sirolimus in the Management of Graft-versus-Host Disease: From Prophylaxis to Treatment

被引：37

作者：

Abouelnasr, Ahmed ^{[1
,2
]}

Roy, Jean ^{[1
]}

Cohen, Sandra ^{[1
]}

Kiss, Thomas ^{[1
]}

Lachance, Silvy ^{[1
]}

机构：

[1] Univ Montreal, Hop Maison Neuve Rosemont, Div Haematol Oncol, Stem Cell Transplant Program, Montreal, PQ H1T 2M4, Canada

[2] Natl Canc Inst Cairo, Cairo, Egypt

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2013年 / 19卷 / 01期

关键词：

Sirolimus role in GHVD; management; STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; PROLIFERATION IN-VITRO; HUMAN DENDRITIC CELLS; REGULATORY T-CELLS; EPSTEIN-BARR-VIRUS; LONG-TERM TRIAL; RENAL-TRANSPLANTATION; THROMBOTIC MICROANGIOPATHY; MYCOPHENOLATE-MOFETIL;

D O I：

10.1016/j.bbmt.2012.06.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). Measures developed that have significantly reduced GVHD were also frequently associated with an increased risk of relapse. GVHD and graft-versus-tumor (GVT) effects are tightly linked, and balance between both reactions is difficult to achieve. To have an impact on the outcome and quality of life after HSCT, improvements in current strategies to prevent and treat GVHD while preserving the GVT effect are clearly needed. Sirolimus (rapamycin) is a lipophilic macrocytic lactone with immunosuppressive, antitumor, and antiviral properties. Because of its multiple modes of activities, it is being increasingly used in the management of GVHD. This review aims to summarize its mechanisms of action and potential advantages over other immunosuppressors and to analyze the most relevant studies investigating its role in both prevention and treatment of GVHD. (C) 2013 American Society for Blood and Marrow Transplantation.

引用

页码：12 / 21

页数：10

共 68 条

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[Anonymous], 0402 BMT CTN

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