European Registry on the management of Helicobacter pylori infection (Hp-EuReg): n analysis of 2360 patients receiving first-line therapy in Russia

被引：7

作者：

Bordin, D. S. ^{[1
,19
]}

Embutnieks, Yu. V. ^{[1
]}

Vologzhanina, L. G. ^{[2
]}

IL'Chishina, T. A. ^{[3
]}

Voinovan, I. N. ^{[1
]}

Sarsenbaeva, A. S. ^{[4
]}

Alekseenko, S. A. ^{[5
]}

Zaitsev, O. V. ^{[6
]}

Abdulkhakov, R. A. ^{[7
]}

Osipenko, M. F. ^{[8
]}

Livzan, M. A. ^{[9
]}

Tsukanov, V. V. ^{[10
]}

Burkov, S. G. ^{[11
]}

Bakulina, N. V. ^{[12
]}

Dekhnich, N. N. ^{[13
]}

Tarasova, L. V. ^{[14
]}

Plotnikova, E. Yu. ^{[15
]}

Maev, I. V. ^{[16
]}

Kucheryavyi, Yu. A. ^{[16
]}

Baryshnikova, N. V. ^{[17
]}

Butov, M. A. ^{[18
]}

Kolbasnikov, S. V. ^{[19
]}

Pakhomova, A. L. ^{[20
]}

Zhestkova, T. V.

Baranovskii, A. Yu. ^{[21
]}

Abdulkhakov, S. R. ^{[22
]}

Ageeva, E. A. ^{[5
]}

Lyalyukova, E. A. ^{[9
]}

Vasyutin, A. V. ^{[10
]}

Golubev, N. N. ^{[11
]}

Savilova, I. V. ^{[12
]}

Morkovkina, L. V. ^{[14
]}

Kononova, A. G. ^{[19
]}

Megraud, F. ^{[23
]}

O'Morain, C. ^{[24
]}

Ramas, M. ^{[25
,26
]}

Nyssen, O. P. ^{[25
,26
]}

Mcnicholl, A. G. ^{[25
,26
]}

Gisbert, J. P. ^{[25
,26
]}

机构：

[1] Moscow Healthcare Dept, AS Loginov Moscow Clin Sci Pract Ctr, Moscow, Russia

[2] Gastrocenter, Perm, Russia

[3] SM Clin, St Petersburg, Russia

[4] South Ural State Med Univ, Minist Hlth Russia, Chelyabinsk, Russia

[5] Far Eastern State Med Univ, Minist Hlth Russia, Khabarovsk, Russia

[6] First Clin Med Ctr, Kovrov, Russia

[7] Kazan State Med Univ, Minist Hlth Russia, Kazan, Russia

[8] Novosibirsk State Med Univ, Minist Hlth Russia, Novosibirsk, Russia

[9] Omsk State Med Univ, Minist Hlth Russia, Omsk, Russia

[10] Russian Acad Sci, Siberian Branch, Krasnoyarsk Sci Ctr, Separat Div Sci Res Inst Med Problems North, Krasnoyarsk, Russia

[11] Dept Presidential Affairs Russian Federat, Polyclin 3, Moscow, Russia

[12] II Michnikov North Western State Med Univ, Minist Hlth Russia, St Petersburg, Russia

[13] Smolensk State Med Univ, Minist Hlth Russia, Smolensk, Russia

[14] IN Ulyanov Chuvash Republ Chuvash State Univ, Minist Hlth, Republican Clin Hosp, Republican Gastroenterol Ctr, Cheboksary, Russia

[15] Kemerovo State Med Univ, Minist Hlth Russia, Kemerovo, Russia

[16] AI Evdokimov Moscow State Med Dent Univ, Minist Hlth Russia, Moscow, Russia

[17] Pavlov First St Petersburg State Med Univ, Minist Hlth Russia, St Petersburg, Russia

[18] IP Pavlov Ryazan State Med Univ, Minist Hlth Russia, Ryazan, Russia

[19] Tver State Med Univ, Minist Hlth Russia, Tver, Russia

[20] Saratov State Med Univ VI Razumovsky, Minist Hlth Russia, Saratov, Russia

[21] St Petersburg State Univ, St Petersburg, Russia

[22] Kazan Volga Reg Fed Univ, Kazan, Russia

[23] Hosp Pellegrin, Lab Bacteriol, Bordeaux, France

[24] Trinity Coll Dublin, Dept Gastroenterol, Tallaght Hosp, Dublin, Ireland

[25] Univ Hosp Princess, Inst Res Hlth Princess IIS IP, Biomed Res Ctr Network Hepat & Digest Dis CIBEReh, Gastroenterol Unit, Madrid, Spain

[26] Autonomous Univ Madrid UAM, Madrid, Spain

来源：

TERAPEVTICHESKII ARKHIV | 2018年 / 90卷 / 02期

关键词：

Helicobacter pylori; Hp-EuReg; register; eradication therapy; BISMUTH; ACCURACY;

D O I：

10.26442/terarkh201890235-42

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

European Registry on the management of Helicobacter pylori infection ("Hp-EuReg") - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pylori and its comparison with international recommendations. Materials and methods. The analysis of 2360 patients entered in the register by the Russian centres of "Hp-EuReg" in 2013-2017, who were underwent 1st line eradication therapy. Results. The most common methods of primary diagnosis of H. pylori are histological (37.7%), rapid urease test (29.2%) and serology (29.7%). The duration of eradication therapy in 9.4% of cases was 7 days, in 65.3% - 10 days, and in 25.3% - 14 days. To control the effectiveness of treatment, H. pylori antigen in feces (31.3%), urea breath test (23.4%) and histological method (23.3%) were used. In 3.6% cases was used serology by mistake. In 17.3% of patients control was not carried out. The effectiveness of triple therapy with a PPI, amoxicillin, clarithromycin (per protocol) was 67.6%, with 7-day course, 81.1 % at 10-day and 86.7% at 14-day course. Eradication rate of triple therapy with addition of bismuth (per protocol) reached 90,6% in the group receiving 10-day scheme and 93.6% in the group receiving the 14-day treatment. Conclusion. Significant deviations of clinical practice from expert recommendations, most pronounced at the stage of monitoring the effectiveness of therapy, were noted. The suboptimal efficacy of triple therapy is shown.

引用

页码：35 / 42

页数：8

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