Synthesis of Pyrrolo[2,1,5-cd]indolizine Rings via Visible-Light-Induced Intermolecular [3+2] Cycloaddition of Indolizines and Alkynes

被引：34
作者：
Zhang, Yu [1 ]
Yu, Yue [1 ]
Liang, Bing-bing [1 ]
Pei, Yong-yan [1 ]
Liu, Xiang [1 ]
Yao, Hua-gang [1 ]
Cao, Hua [1 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 16期
关键词：
FUNCTIONALIZATION; CONSTRUCTION; DERIVATIVES; CYCLIZATION; ARYLATION; ESTERS;
D O I：
10.1021/acs.joc.0c01253
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A range of indolizine smoothly underwent visible-light-induced intermolecular [3+2] annulations with internal alkynes to afford pyrrolo[2,1,5-cd]indolizine in good to excellent yields with high regioselectivity. Through this cascade reaction, a series of fluoroactive fused indolizines with a large pi-system were conveniently synthesized. The usage of visible light as energy source with air as a stoichiometric oxidant under simple conditions makes this process attractive and practical.
引用
收藏
页码：10719 / 10727
页数：9
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