Switching on the green light for chimeric antigen receptor T-cell therapy

被引：13

作者：

Mardiana, Sherly ^{[1
,2
]}

Lai, Junyun ^{[1
,2
]}

House, Imran Geoffrey ^{[1
,2
]}

Beavis, Paul Andrew ^{[1
,2
]}

Darcy, Phillip Kevin ^{[1
,2
,3
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia

[3] Univ Melbourne, Dept Pathol, Parkville, Vic, Australia

[4] Monash Univ, Dept Immunol, Clayton, Vic, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2019年 / 8卷 / 05期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

CAR; adoptive cell therapy; solid tumors; T cells; PD-1; BLOCKADE; ANTITUMOR-ACTIVITY; IN-VITRO; COMBINATION IMMUNOTHERAPY; SOLID TUMORS; CD19; CAR; B-CELL; ADOPTIVE IMMUNOTHERAPY; 4-1BB COSTIMULATION; DENDRITIC CELLS;

D O I：

10.1002/cti2.1046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adoptive cellular therapy involving genetic modification of T cells with chimeric antigen receptor (CAR) transgene offers a promising strategy to broaden the efficacy of this approach for the effective treatment of cancer. Although remarkable antitumor responses have been observed following CAR T-cell therapy in a subset of B-cell malignancies, this has yet to be extended in the context of solid cancers. A number of promising strategies involving reprogramming the tumor microenvironment, increasing the specificity and safety of gene-modified T cells and harnessing the endogenous immune response have been tested in preclinical models that may have a significant impact in patients with solid cancers. This review will discuss these exciting new developments and the challenges that must be overcome to deliver a more sustained and potent therapeutic response.

引用

页数：16

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