Antigen presenting cell/tumor cell fusion vaccines for cancer immunotherapy

被引：16

作者：

Browning, Michael J. ^{[1
,2
]}

机构：

[1] Univ Leicester, Dept Infect Immun & Inflammat, Leicester, Leics, England

[2] Leicester Royal Infirm, Dept Immunol, Leicester, Leics, England

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2013年 / 9卷 / 07期

关键词：

antigen presenting cell; cancer; tumour; hybrid; fusion; vaccine; CYTOTOXIC T-LYMPHOCYTES; PREVENT TUMOR-GROWTH; DENDRITIC CELLS; ANTITUMOR IMMUNITY; MULTIPLE-MYELOMA; IN-VITRO; CLINICAL-RESPONSES; HYBRID VACCINATION; MALIGNANT-MELANOMA; CARCINOMA-CELLS;

D O I：

10.4161/hv.24235

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fusions of antigen presenting cells and tumor cells have been investigated in animal models and phase I/II clinical trials as candidate cancer vaccines. In animal studies there have been numerous reports of induction of protective immunity against a wide range of tumor types. Results of clinical trials have been less dramatic, but tumor-specific immune responses have been reported in many patients, with clinical responses to the vaccination in a subset. In this commentary article, I review the current status of antigen presenting cell/tumor cell fusion vaccines for cancer immunotherapy.

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页码：1545 / 1548

页数：4

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