PRECLINICAL X-RAY DARK-FIELD RADIOGRAPHY FOR PULMONARY EMPHYSEMA EVALUATION

被引：0

作者：

Yaroshenko, A. ^{[1
]}

Meinel, F. G. ^{[2
]}

Bech, M. ^{[1
,3
]}

Tapfer, A. ^{[1
]}

Velroyen, A. ^{[1
]}

Schleede, S. ^{[1
]}

Mueller, M. ^{[1
]}

Auweter, S. ^{[2
]}

Bohla, A. ^{[4
]}

Yildirim, A. Oe ^{[4
]}

Nikolaou, K. ^{[2
]}

Bamberg, F. ^{[2
]}

Eickelberg, O. ^{[4
]}

Reiser, M. ^{[2
]}

Pfeiffer, F. ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Phys, D-80290 Munich, Germany

[2] Ludwig Maximilians Univ Hosp Munich, Inst Clin Radiol, Munich, Germany

[3] Lund Univ, Med Radiat Phys, S-22100 Lund, Sweden

[4] Comprehens Pneumol Ctr, Inst Lung Biol & Dis Helmholtz Zentrum Munich, Munich, Germany

来源：

2013 IEEE 10TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI) | 2013年

基金：

欧洲研究理事会;

关键词：

dark-field; emphysema; grating interferometer; phase-contrast; x-ray; COMPUTED-TOMOGRAPHY; CONTRAST; COPD; MICE; CT;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.

引用

页码：370 / 373

页数：4

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