Dendritic cell-based immunotherapy

被引：676

作者：

Sabado, Rachel L. ^{[1
]}

Balan, Sreekumar ^{[1
]}

Bhardwaj, Nina ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

来源：

CELL RESEARCH | 2017年 / 27卷 / 01期

关键词：

dendritic cell; immunotherapy; CERVICAL-CANCER PATIENTS; REGULATORY T-CELLS; INTEGRATED IMMUNE-RESPONSE; LONG PEPTIDE VACCINE; MELANOMA PATIENTS; IN-VIVO; SIPULEUCEL-T; LYMPH-NODES; LISTERIA-MONOCYTOGENES; ANTITUMOR IMMUNITY;

D O I：

10.1038/cr.2016.157

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunotherapy using dendritic cell (DC)-based vaccination is an approved approach for harnessing the potential of a patient's own immune system to eliminate tumor cells in metastatic hormone-refractory cancer. Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical outcome, there remains no consensus on how to manufacture DC vaccines. In this review we will discuss what has been learned thus far about human DC biology from clinical studies, and how current approaches to apply DC vaccines in the clinic could be improved to enhance anti-tumor immunity.

引用

页码：74 / 95

页数：22

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