Clearance of Chronic HCV Infection During Acute Delta Hepatitis

被引：22

作者：

Deterding, K. ^{[1
]}

Pothakamuri, S. V. ^{[1
]}

Schlaphoff, V. ^{[1
]}

Hadem, J. ^{[1
]}

Metzler, F. ^{[1
]}

Bahr, M. J. ^{[1
]}

Manns, M. P. ^{[1
]}

Cornberg, M. ^{[1
]}

Wedemeyer, H. ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany

来源：

INFECTION | 2009年 / 37卷 / 02期

关键词：

C VIRUS-INFECTION; T-CELL RESPONSES; B-VIRUS; TRANSGENIC MICE; CORE PROTEIN; REPLICATION; SUPERINFECTION; SUPPRESSION; INHIBITION; INTERFERON;

D O I：

10.1007/s15010-007-7204-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The course of chronic hepatitis C in acute HDV/HBV superinfection is unknown. Here, we report a patient with chronic hepatitis C who cleared HCV during acute self-limited hepatitis B/D superinfection. Recovery from HCV was associated with the appearance of a strong and multispecific HDV-specific memory CD4+ and CD8+ T cell response - but only weak HCV-specific CD4+ T cell responses. These data suggest that HCV can be cleared by bystander mechanisms during acute infections with other pathogens which may be considered in the development of immunotherapies for hepatitis C.

引用

页码：159 / 162

页数：4

共 25 条

[1] Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice [J].

Cavanaugh, VJ ;

Guidotti, LG ;

Chisari, FV .

JOURNAL OF VIROLOGY, 1998, 72 (04) :2630-2637

[2] Hepatitis A virus infection suppresses hepatitis C virus replication and may lead to clearance of HCV [J].

Deterding, Katja ;

Tegmeyer, Bjoern ;

Cornberg, Markus ;

Hadem, Johannes ;

Potthoff, Andrej ;

Boeker, Klaus H. W. ;

Tillmann, Hans L. ;

Manns, Michael P. ;

Wedemeyer, Heiner .

JOURNAL OF HEPATOLOGY, 2006, 45 (06) :770-778

[3] Hepatitis A virus infection in hepatitis C Brazilian patients [J].

Devalle, S ;

de Paula, VS ;

de Oliveira, JM ;

Niel, C ;

Gaspar, AMC .

JOURNAL OF INFECTION, 2003, 47 (02) :125-128

[4] Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway [J].

Frese, M ;

Pietschmann, T ;

Moradpour, D ;

Haller, O ;

Bartenschlager, R .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :723-733

[5] Hepatitis C virus eradication associated with hepatitis B virus superinfection and development of a hepatitis B virus specific T cell response [J].

Gruener, NH ;

Jung, MC ;

Ulsenheimer, A ;

Gerlach, TJ ;

Diepolder, HM ;

Schirren, CA ;

Hoffmann, R ;

Wächtler, M ;

Backmund, M ;

Pape, GR .

JOURNAL OF HEPATOLOGY, 2002, 37 (06) :866-869

[6] Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver [J].

Guidotti, LG ;

Borrow, P ;

Hobbs, MV ;

Matzke, B ;

Gresser, I ;

Oldstone, MBA ;

Chisari, FV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) :4589-4594

[7] Noncytolytic control of viral infections by the innate and adaptive immune response [J].

Guidotti, LG ;

Chisari, FV .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :65-91

[8] Effect of alpha interferon on the hepatitis C virus replicon [J].

Guo, JT ;

Bichko, VV ;

Seeger, C .

JOURNAL OF VIROLOGY, 2001, 75 (18) :8516-8523

[9] Role of hepatitis B, C, and D viruses in dual and triple infection: Influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference [J].

Jardi, R ;

Rodriguez, F ;

Buti, M ;

Costa, X ;

Cotrina, M ;

Galimany, R ;

Esteban, R ;

Guardia, J .

HEPATOLOGY, 2001, 34 (02) :404-410

[10] Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy [J].

Lauer, GM ;

Lucas, M ;

Timm, J ;

Ouchi, K ;

Kim, AY ;

Day, CL ;

zur Wiesch, JS ;

Paranhos-Baccala, G ;

Sheridan, I ;

Casson, DR ;

Reiser, M ;

Gandhi, RT ;

Li, B ;

Allen, TM ;

Chung, RT ;

Klenerman, P ;

Walker, BD .

JOURNAL OF VIROLOGY, 2005, 79 (20) :12979-12988

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