Kisspeptin and seasonality in sheep

被引：71

作者：

Clarke, Iain J. ^{[1
]}

Smith, Jeremy T. ^{[1
]}

Caraty, Alain ^{[2
]}

Goodman, Robert L. ^{[3
]}

Lehman, Michael N. ^{[4
]}

机构：

[1] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia

[2] Univ Tours Haras Nationaux, CNRS, INRA, UMR Physiol Reprod & Comportements 6175, F-37380 Nouzilly, France

[3] W Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV 26505 USA

[4] Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada

来源：

PEPTIDES | 2009年 / 30卷 / 01期

关键词：

GnRH; Photoperiod; Estrogen; GONADOTROPIN-RELEASING-HORMONE; NEGATIVE FEEDBACK ACTION; ESTROGEN-RECEPTOR-ALPHA; OVINE PREOPTIC AREA; ARCUATE NUCLEUS; NEUROKININ-B; LH-SECRETION; OVARIECTOMIZED EWES; DAY LENGTH; ESTRADIOL;

D O I：

10.1016/j.peptides.2008.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sheep are seasonal breeders, experiencing a period of reproductive quiescence during spring and early summer. During the non-breeding period, kisspeptin expression in the arcuate nucleus is markedly reduced. This strongly suggests that the mechanisms that control seasonal changes in reproductive function involve kisspeptin neurons. Kisspeptin cells appear to regulate GnRH neurons and transmit sex-steroid feedback to the reproductive axis. Since the non-breeding season is characterized by increased negative feedback of estrogen on GnRH secretion, the kisspeptin neurons seem to be fundamentally involved in the determination of breeding state. The reduction in kisspeptin neuronal function during the non-breeding season can be corrected by infusion of kisspeptin, which causes ovulation in seasonally acyclic females. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：154 / 163

页数：10

共 39 条

[1] Morphological plasticity in the neural circuitry responsible for seasonal breeding in the ewe [J].

Adams, Van L. ;

Goodman, Robert L. ;

Salm, A. K. ;

Coolen, Lique M. ;

Karsch, Fred J. ;

Lehman, Michael N. .

ENDOCRINOLOGY, 2006, 147 (10) :4843-4851

[2] Gonadotropin-inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken-gonadotropin-releasing hormone [J].

Bentley, GE ;

Perfito, N ;

Ukena, K ;

Tsutsui, K ;

Wingfield, JC .

JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (08) :794-802

[3] Kisspeptin synchronizes Preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes [J].

Caraty, A. ;

Smith, J. T. ;

Lomet, D. ;

Ben Saied, S. ;

Morrissey, A. ;

Cognie, J. ;

Doughton, B. ;

Baril, G. ;

Briant, C. ;

Clarke, I. J. .

ENDOCRINOLOGY, 2007, 148 (11) :5258-5267

[4] Evidence that the mediobasal hypothalamus is the primary site of action of estradiol in inducing the preovulatory gonadotropin releasing hormone surge in the ewe [J].

Caraty, A ;

Fabre-nys, C ;

Delaleu, B ;

Locatelli, A ;

Bruneau, G ;

Karsch, FJ ;

Herbison, A .

ENDOCRINOLOGY, 1998, 139 (04) :1752-1760

[5] DIRECT PITUITARY EFFECTS OF ESTROGEN AND PROGESTERONE ON GONADOTROPIN-SECRETION IN THE OVARIECTOMIZED EWE [J].

CLARKE, IJ ;

CUMMINS, JT .

NEUROENDOCRINOLOGY, 1984, 39 (03) :267-274

[6]

CLARKE IJ, 1987, OXFORD REV REPROD B, V9, P54

[7] THE TEMPORAL RELATIONSHIP BETWEEN GONADOTROPIN-RELEASING HORMONE (GNRH) AND LUTEINIZING-HORMONE (LH) SECRETION IN OVARIECTOMIZED EWES [J].

CLARKE, IJ ;

CUMMINS, JT .

ENDOCRINOLOGY, 1982, 111 (05) :1737-1739

[8] VARIABLE PATTERNS OF GONADOTROPIN-RELEASING-HORMONE SECRETION DURING THE ESTROGEN-INDUCED LUTEINIZING-HORMONE SURGE IN OVARIECTOMIZED EWES [J].

CLARKE, IJ .

ENDOCRINOLOGY, 1993, 133 (04) :1624-1632

[9]

CLARKE IJ, ENDOCRINOLO IN PRESS

[10]

CLARKE IJ, 1996, AUTONOMIC NERVOUS SY, P45

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