Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

被引：67

作者：

Daumann, Lena J. ^{[1
]}

Schenk, Gerhard ^{[1
]}

Ollis, David L. ^{[2
]}

Gahan, Lawrence R. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

PURPLE ACID-PHOSPHATASE; METALLO-BETA-LACTAMASE; POTENTIAL BIOLOGICAL SIGNIFICANCE; ORGANOPHOSPHATE-DEGRADING ENZYME; BINUCLEAR MANGANESE COMPOUNDS; MAGNETIC CIRCULAR-DICHROISM; SCHIFF-BASE COMPLEXES; DICOBALT II-II; ACTIVE-SITE; ELECTRONIC-STRUCTURE;

D O I：

10.1039/c3dt52287c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

引用

页码：910 / 928

页数：19

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