Fatal West Nile virus infection after rituximab/rludarabine-induced remission for non-Hodgkin's lymphoma

被引：27
作者：
Mawhorter, SD
Sierk, A
Staugaitis, SM
Avery, RK
Sobecks, R
Prayson, RA
Procop, GW
Yen-Lieberman, B
机构：
[1] Cleveland Clin Fdn, Dept Infect Dis, Cleveland, OH 44195 USA
[2] Case Western Reserve Univ, Lakewood Hosp, Dept Pathol, Cleveland, OH 44106 USA
[3] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA
[4] Cleveland Clin Fdn, Dept Hematol & Oncol, Cleveland, OH 44195 USA
[5] Cleveland Clin Fdn, Dept Clin Pathol, Clin Microbiol Sect, Cleveland, OH 44195 USA
来源：
CLINICAL LYMPHOMA & MYELOMA | 2005年 / 6卷 / 03期
关键词：
diagnosis; humoral immunity; immunocompromised patients; polymerase chain reaction; serology;
D O I：
10.3816/CLM.2005.n.053
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
West Nile virus (WNV) infections are potentially life threatening in immunocompromised hosts. Currently, the best diagnostic test is serology. Reverse-transcriptase polymerase chain reaction (RT-PCR) testing has a role, but, because WNV is a cell-associated neurotropic virus, RT-PCR results are frequently negative even in cases of active infection. We present a case in which serology results were persistently negative because the patient was immunocompromised following lymphoma treatment. The role of humoral immunity in resolution of WNV is also discussed.
引用
收藏
页码：248 / 250
页数：3
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