2,6-diaminopurine in TNA: Effect on duplex stabilities and on the efficiency of template-controlled ligations

被引：59
作者：
Wu, XL
Delgado, G
Krishnamurthy, R
Eschenmoser, A
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 08期
关键词：
D O I：
10.1021/ol020016p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHIC] Replacement of adenine by 2,6-diaminopurine-two nucleobases to be considered equivalent from an etiological point of view-strongly enhances the stability of TNA/TNA, TNA/RNA, or TNA/DNA duplexes and efficiently accelerates template-directed ligation of TNA ligands.
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页码：1283 / 1286
页数：4
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