2,6-diaminopurine in TNA: Effect on duplex stabilities and on the efficiency of template-controlled ligations

被引：58
作者：
Wu, XL
Delgado, G
Krishnamurthy, R
Eschenmoser, A
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ORGANIC LETTERS | 2002年 / 4卷 / 08期
关键词：
D O I：
10.1021/ol020016p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHIC] Replacement of adenine by 2,6-diaminopurine-two nucleobases to be considered equivalent from an etiological point of view-strongly enhances the stability of TNA/TNA, TNA/RNA, or TNA/DNA duplexes and efficiently accelerates template-directed ligation of TNA ligands.
引用
收藏
页码：1283 / 1286
页数：4
相关论文
共 36 条
  • [1] Pyranosyl-RNA: Chiroselective self-assembly of base sequences by ligative oligomerization of tetranucleotide-2',3'-cyclophosphates (with a commentary concerning the origin of biomolecular homochirality)
    Bolli, M
    Micura, R
    Eschenmoser, A
    [J]. CHEMISTRY & BIOLOGY, 1997, 4 (04): : 309 - 320
  • [2] Pyranosyl-RNA: Further observations on replication
    Bolli, M
    Micura, R
    Pitsch, S
    Eschenmoser, A
    [J]. HELVETICA CHIMICA ACTA, 1997, 80 (06) : 1901 - 1951
  • [3] Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil as base moiety
    Boudou, V
    Kerremans, L
    De Bouvere, B
    Lescrinier, E
    Schepers, G
    Busson, R
    Van Aerschot, A
    Herdewijn, P
    [J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (06) : 1450 - 1456
  • [4] THERMODYNAMIC STUDIES OF BASE-PAIRING INVOLVING 2,6-DIAMINOPURINE
    CHEONG, C
    TINOCO, I
    CHOLLET, A
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (11) : 5115 - 5122
  • [5] THE USE OF BRCN FOR ASSEMBLING MODIFIED DNA DUPLEXES AND DNA-RNA HYBRIDS - COMPARISON WITH WATER-SOLUBLE CARBODIIMIDE
    DOLINNAYA, NG
    SOKOLOVA, NI
    ASHIRBEKOVA, DT
    SHABAROVA, ZA
    [J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (11) : 3067 - 3072
  • [6] SITE-DIRECTED MODIFICATION OF DNA DUPLEXES BY CHEMICAL LIGATION
    DOLINNAYA, NG
    SOKOLOVA, NI
    GRYAZNOVA, OI
    SHABAROVA, ZA
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (09) : 3721 - 3738
  • [7] Chemical ligation as a method for the assembly of double-stranded nucleic acids: Modifications and local structure studies
    Dolinnaya, NG
    Shabarova, ZA
    [J]. RUSSIAN CHEMICAL BULLETIN, 1996, 45 (08) : 1787 - 1809
  • [8] THE INFLUENCE OF THE PURINE 2-AMINO GROUP ON DNA CONFORMATION AND STABILITY .2. SYNTHESIS AND PHYSICAL CHARACTERIZATION OF D[CGT(2-NH2)ACG], D[CGU(2-NH2)ACG], AND D[CGT(2-NH2)AT(2-NH2)ACG]
    GAFFNEY, BL
    MARKY, LA
    JONES, RA
    [J]. TETRAHEDRON, 1984, 40 (01) : 3 - 13
  • [9] Hartel C, 2000, HELV CHIM ACTA, V83, P2541, DOI 10.1002/1522-2675(20000906)83:9<2541::AID-HLCA2541>3.0.CO
  • [10] 2-8
1234