Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

被引：30

作者：

Chaudhuri, Julian B. ^{[2
]}

Davidson, Matthew G. ^{[1
]}

Ellis, Marianne J. ^{[2
]}

Jones, Matthew D. ^{[1
]}

Wu, XuJun ^{[1
,2
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Univ Bath, Dept Chem Engn, Ctr Regenerat Med, Bath BA2 7AY, Avon, England

来源：

MACROMOLECULAR SYMPOSIA | 2008年 / 272卷

关键词：

biodegradable; honeycomb; scaffold; thin film; tissue engineering; POLYMER-FILMS; POROUS FILMS; WATER; TEMPLATES; MEMBRANES; PATTERNS; ACID); SIZE;

D O I：

10.1002/masy.200851206

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.

引用

页码：52 / 57

页数：6