Fabrication of Honeycomb-Structured Poly(DL-lactide) and Poly[(DL-lactide)-co-glycolide)] Films and their Use as Scaffolds for Osteoblast-Like Cell Culture

被引：30
|
作者：
Chaudhuri, Julian B. [2 ]
Davidson, Matthew G. [1 ]
Ellis, Marianne J. [2 ]
Jones, Matthew D. [1 ]
Wu, XuJun [1 ,2 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] Univ Bath, Dept Chem Engn, Ctr Regenerat Med, Bath BA2 7AY, Avon, England
来源：
MACROMOLECULAR SYMPOSIA | 2008年 / 272卷
关键词：
biodegradable; honeycomb; scaffold; thin film; tissue engineering; POLYMER-FILMS; POROUS FILMS; WATER; TEMPLATES; MEMBRANES; PATTERNS; ACID); SIZE;
D O I：
10.1002/masy.200851206
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Surfactant-free honeycomb-structured Poly(DL-lactide) (PDLLA) and Poly(DLlactide-co-glycolide) PDLLGA thin films were fabricated by water droplet templating methods. Thin films with uniform pore structure were obtained after controlled evaporation of solvents in a humid atmosphere. Solvent, polymer concentration and humidity were found to be important factors in the formation of honeycomb-structured thin films. Preliminary cell culture studies with MG-63 osteoblast-like cell lines showed promising degrees of cell attachment and proliferation on these films, suggesting that they are applicable as scaffolds for tissue engineering.
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页码：52 / 57
页数：6
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