Nobiletin suppresses monocyte chemoattractant protein-1 (MCP-1) expression by regulating MAPK signaling in 3T3-L1 cells

被引：4
|
作者：
Yasunaga, Sho [1 ]
Domen, Miku [2 ]
Nishi, Kosuke [2 ,3 ]
Kadota, Ayumu [4 ]
Sugahara, Takuya [2 ,3 ]
机构：
[1] Ehime Univ, United Grad Sch Agr Sci, Matsuyama, Ehime 7908566, Japan
[2] Ehime Univ, Grad Sch Agr, 3-5-7 Tarumi, Matsuyama, Ehime 7908566, Japan
[3] Ehime Univ, Food & Hlth Sci Res Ctr, Matsuyama, Ehime 7908566, Japan
[4] Ikata Serv Co Ltd, Ikata, Ehime 7690421, Japan
来源：
JOURNAL OF FUNCTIONAL FOODS | 2016年 / 27卷
关键词：
Nobiletin; MCP-1; Chemokines; Adipocyte hypertrophy; 3T3-L1; cells; Tumor necrosis factor alpha; ADIPOCYTE DIFFERENTIATION; ADIPOSE-TISSUE; CC-CHEMOKINE; ACTIVATION; INSULIN; PHOSPHORYLATION; PHOSPHATASE-1; INFLAMMATION; RELEASE; OBESITY;
D O I：
10.1016/j.jff.2016.09.025
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Nobiletin is a major citrus flavonoid possessing several biological activities. Nobiletin has been reported to display anti-inflammatory activity and to reduce monocyte chemoattractant protein (MCP)-1 secretion by 3T3-L1 adipocytes. However, its mode of action remains unclear. In the present study, we investigated the suppressive effect of nobiletin on MCP-1 expression in 3T3-L1 cells and its underlying molecular mechanism. Nobiletin notably down regulated the MCP-1 mRNA level during adipocyte differentiation. Nobiletin also reduced MCP-1 secretion by preadipocytes (undifferentiated cells), differentiated adipocytes, and hypertrophied adipocytes. Immunoblot analysis showed that nobiletin inhibits the phosphorylation level of extracellular signal-regulated kinase (ERK) in both preadipocytes and differentiated adipocytes. Moreover, nobiletin suppressed MCP-1 secretion by adipocytes induced by tumor necrosis factor (TNF)-alpha. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：406 / 415
页数：10
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