New and Efficient Synthesis of 2,3,4-Trisubstituted 2H-Pyrrolo[3,4-c]quinolines via a MCR/Staudinger/Aza-Wittig Sequence

被引：15

作者：

Qu, Feng ^{[1
]}

Hu, Ruo-Fei ^{[1
]}

Gao, Le ^{[1
]}

Wu, Jing ^{[1
]}

Cheng, Xiao-Hong ^{[2
]}

Wang, Song ^{[2
]}

He, Ping ^{[1
,2
]}

机构：

[1] Hubei Univ Arts & Sci, Coll Chem Engn & Food Sci, Xiangyang 441053, Hubei Province, Peoples R China

[2] Hubei Univ Arts & Sci, Hubei Key Lab Low Dimens Optoelect Mat & Devices, Xiangyang 441053, Hubei Province, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 23期

基金：

中国国家自然科学基金;

关键词：

2H-pyrrolo[3; 4-c]quinolones; multicomponent reaction; azide; aza-Wittig reaction; iminophosphorane; HIGHLY SUBSTITUTED PYRROLES; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; FUNCTIONALIZED PYRROLES; 4-COMPONENT SYNTHESIS; DERIVATIVES; AMINES;

D O I：

10.1055/s-0035-1560208

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient method for the construction of 2,3,4-trisubstituted 2H-pyrrolo[3,4-c]quinoline derivatives was developed. Starting from easily accessible 2-azidobenzaldehyde, nitromethane, 1,3-dicarbonyl compounds, and various amines gave the multicomponent reaction (MCR) products, 1-substituted 3-acyl-4-(2-azidophenyl)-2-methyl-1H-pyrroles, that underwent Staudinger/aza-Wittig cyclization of in the presence of triphenylphosphine to give the final products.

引用

收藏

页码：3701 / 3710

页数：10

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