Virus-based fabrication of micro- and nanofibers using electrospinning

被引：159
作者：
Lee, SW
Belcher, AM
机构：
[1] MIT, Dept Mat Sci & Engn & Biol Engn, Cambridge, MA 02139 USA
[2] Univ Texas, Austin, TX 78712 USA
来源：
NANO LETTERS | 2004年 / 4卷 / 03期
关键词：
D O I：
10.1021/nl034911t
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Long rod-shaped M13 viruses were used to fabricate one-dimensional (1D) micro- and nanosized diameter fibers by mimicking the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in a crosslinking solution of glutaraldehyde. Resulting fibers were 10-20 mum in diameter. AFM imaging verified that the molecular long axis of the virus fibers was parallel to the fiber long axis. M13 viruses were suspended in 1,1,1,3,3,3-hexafluoro-2-propanoI and were then electrospun into fibers. After blending with a highly water soluble polymer, polyvinyl pyrolidone (PVP), M13 viruses were spun into continuous uniform virus-blended PVP (virus-PVP) nanofibers. Resulting virus-PVP electrospun fibers maintained their ability to infect bacterial hosts after resuspending in buffer solution.
引用
收藏
页码：387 / 390
页数：4
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