Applying the IWG Research Criteria in Clinical Practice Feasibility and Ethical Issues

被引：10

作者：

Molinuevo, Jose L. ^{[1
,2
]}

Rami, Lorena ^{[1
,2
]}

机构：

[1] Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, E-08036 Barcelona, Spain

[2] Inst Invest Biomed August Pi i Sunyer, Neurodegenerat Dis Grp, Barcelona 08036, Spain

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 03期

关键词：

Alzheimer disease; Diagnosis; Biomarkers; Bioethics; POSITRON-EMISSION-TOMOGRAPHY; ALZHEIMERS-DISEASE; DIAGNOSIS; AUTOPSY;

D O I：

10.1016/j.mcna.2012.12.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2007, new International Working Group research criteria introduced a new conceptualization of Alzheimer disease and created a framework for earlier diagnosis. There is increasing consensus to understand Alzheimer disease as a clinical-biologic entity, in which biomarkers, especially pathophysiologic markers revealing underlying pathology, represent the biologic counterpart of the diagnosis, and specific symptoms, such as episodic memory deficits, account for the clinical one. This article advances and moves forward on this.

引用

页码：477 / +

页数：9

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