CEREBROSPINAL FLUID ANGIOGENIN LEVEL IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS

被引:0
作者
Ilzecka, Joanna [1 ]
机构
[1] Lublin Med Univ, Dept Neurol Rehabil, Lublin, Poland
关键词
Amyotrophic Lateral Sclerosis; Neurodegenerative Diseases; Cerebrospinal Fluid; Angiogenesis inducing agents;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. It is Suggested that angiogenin (ANG) may play a role in the pathomechanism of this disease. The aim of the Study was to measure cerebrospinal fluid (CSF) ANG levels in patients with ALS. Twenty ALS patients and 15 control subjects were included in the study CSF ANG levels were Measured by ELISA. Study results showed that CSF ANG level did not differ between ALS patients and control group (p > 0.05). There was no significant correlation between CSF ANG level and clinical state of ALS patients either (p > 0.05). The present study conducted on CSF of patients with ALS did not confirm previous observation on the possible role of ANG in neurodegeneration in this disease.
引用
收藏
页码:77 / 79
页数:3
相关论文
共 15 条
[1]   The angiogenins: An emerging family of ribonuclease related proteins with diverse cellular functions [J].
Adams S.A. ;
Subramanian V. .
Angiogenesis, 1999, 3 (3) :189-199
[3]  
Bruijn Lucie I, 2006, Expert Rev Neurother, V6, P417, DOI 10.1586/14737175.6.3.417
[4]   Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population [J].
Corrado, Lucia ;
Battistini, Stefania ;
Penco, SilVana ;
Bergarnaschi, Laura ;
Testa, Lucia ;
Ricci, Claudia ;
Glannini, Fablo ;
Greco, Giuseppe ;
Patrosso, Maria Cristina ;
Pileggi, Simona ;
Causarano, Renzo ;
Mazzini, Letizia ;
Momigliano-Richiardi, Patricia ;
D'Alfonso, Sandra .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 258 (1-2) :123-127
[5]   Elevated serum angiogenin levels in ALS [J].
Cronin, S. ;
Greenway, M. J. ;
Ennis, S. ;
Kieran, D. ;
Green, A. ;
Prehn, J. H. M. ;
Hardiman, O. .
NEUROLOGY, 2006, 67 (10) :1833-1836
[6]   ALSFRS-R [J].
Gordon, PH ;
Miller, RG ;
Moore, DH .
AMYOTROPHIC LATERAL SCLEROSIS, 2004, 5 :90-93
[7]   ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis [J].
Greenway, MJ ;
Andersen, PM ;
Russ, C ;
Ennis, S ;
Cashman, S ;
Donaghy, C ;
Patterson, V ;
Swingler, R ;
Kieran, D ;
Prehn, J ;
Morrison, KE ;
Green, A ;
Acharya, KR ;
Brown, RH ;
Hardiman, O .
NATURE GENETICS, 2006, 38 (04) :411-413
[8]   A novel candidate region for ALS on chromosome 14q11.2 [J].
Greenway, MJ ;
Alexander, MD ;
Ennis, S ;
Traynor, BJ ;
Corr, B ;
Frost, E ;
Green, A ;
Hardiman, O .
NEUROLOGY, 2004, 63 (10) :1936-1938
[9]   Transplantation of angiogenin-overexpressing mesenchymal stem cells synergistically augments cardiac function in a porcine model of chronic ischemia [J].
Huang, Sheng-Dong ;
Lu, Fang-Lin ;
Xu, Xun-Yu ;
Liu, Xiao-Hong ;
Zhao, Xian-Xian ;
Zhao, Bao-Zhen ;
Wang, Li ;
Gong, De-Jun ;
Yuan, Yang ;
Xu, Zhi-Yun .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2006, 132 (06) :1329-1338
[10]   Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells [J].
Kim, Hye-Mi ;
Kang, Dong-Ku ;
Kim, Hak Yong ;
Kang, Sang Sun ;
Chang, Soo-Ik .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 352 (02) :509-513