New milbemycin metabolites from the genetically engineered strain Streptomyces bingchenggensis BCJ60

被引：10

作者：

Li, Jian-Song ^{[1
]}

Du, Min-Na ^{[3
]}

Zhang, Hui ^{[3
]}

Zhang, Ji ^{[1
]}

Zhang, Shao-Yong ^{[2
]}

Wang, Hai-Yan ^{[1
]}

Chen, An-Liang ^{[2
]}

Wang, Ji-Dong ^{[2
,3
]}

Xiang, Wen-Sheng ^{[1
]}

机构：

[1] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin, Peoples R China

[2] Zhejiang Agr & Forestry Univ, Sch Forestry & Biotechnol, Prov Joint Engn Lab Biopesticide Preparat, Linan, Peoples R China

[3] Zhejiang Hisun Pharmaceut Co Ltd, Dept New Drug Screening, Taizhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Milbemycin derivatives; genetically engineered strain; Streptomyces bingchenggensis BCJ60; acaricidal activity; nematocidal activity; DERIVATIVES; BIOSYNTHESIS; AVERMECTINS; POLYKETIDE;

D O I：

10.1080/14786419.2016.1244194

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new milbemycin derivatives, 27-methoxylmilbemycin (31) (1) and 27-oxomilbemycin (31) (2), were isolated from the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by 1D NMR, 2D NMR and HR-ESI-MS spectral analysis, and comparison with previous reports. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.

引用

页码：780 / 784

页数：5

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