Monocytosis has adverse prognostic significance and impacts survival in patients with T-cell lymphomas

被引：26

作者：

Bari, Alessia ^{[1
]}

Tadmor, Tamar ^{[2
]}

Sacchi, Stefano ^{[1
]}

Marcheselli, Luigi ^{[1
]}

Liardo, Eliana Valentina ^{[1
]}

Pozzi, Samantha ^{[1
]}

Luminari, Stefano ^{[1
]}

Baldini, Luca ^{[3
]}

Marmiroli, Sandra ^{[4
]}

Federico, Massimo ^{[1
]}

Polliack, Aaron ^{[5
,6
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Diagnost Clin & Publ Hlth Med, I-41124 Modena, Italy

[2] Technion Israel Inst Technol, Rappaport Fac Med, Bnai Zion Med Ctr, Div Hematol, Haifa, Israel

[3] Univ Milan, Fdn IRCCS Ca Granda, Div Hematol, I-20122 Milan, Italy

[4] Univ Modena & Reggio Emilia, Dept Surg Med Odontoiatr & Morphol Sci, Cellular Signaling Lab, I-41124 Modena, Italy

[5] Hadassah Univ Hosp, Dept Hematol, IL-91120 Jerusalem, Israel

[6] Hebrew Univ Jerusalem, Sch Med, IL-91010 Jerusalem, Israel

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 06期

关键词：

Monocytosis; Non-Hodgkin lymphoma; Peripheral T-cell lymphoma; Prognostic value; Overall survival; NON-HODGKINS-LYMPHOMA; UNSPECIFIED PTCL-U; ABSOLUTE MONOCYTE; LYMPHOPENIA; EXPRESSION; DIAGNOSIS; COUNT; MODEL; SCORE; SIGNATURES;

D O I：

10.1016/j.leukres.2013.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this retrospective study we evaluated the prognostic impact of peripheral blood monocytosis in patients with T-cell non Hodgkin lymphomas with "aggressive-typically nodal presentation". In this dataset monocytes >0.8 x 10(9)/L had a strong and statistically significant negative impact on overall survival (OS). In univariate analysis several parameters, including age >60 years, advanced stage, bone marrow involvement, ECOG PS > 1, high LDH level, monocytes >0.8 x 10(9)/L, hemoglobin < 120 g/L, albumin < 35 g/L) had a negative influence on outcome, but in multivariate analysis, monocytosis alone had a stronger association with poor OS. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：619 / 623

页数：5

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