Monocytosis has adverse prognostic significance and impacts survival in patients with T-cell lymphomas

被引：25
作者：
Bari, Alessia [1 ]
Tadmor, Tamar [2 ]
Sacchi, Stefano [1 ]
Marcheselli, Luigi [1 ]
Liardo, Eliana Valentina [1 ]
Pozzi, Samantha [1 ]
Luminari, Stefano [1 ]
Baldini, Luca [3 ]
Marmiroli, Sandra [4 ]
Federico, Massimo [1 ]
Polliack, Aaron [5 ,6 ]
机构：
[1] Univ Modena & Reggio Emilia, Dept Diagnost Clin & Publ Hlth Med, I-41124 Modena, Italy
[2] Technion Israel Inst Technol, Rappaport Fac Med, Bnai Zion Med Ctr, Div Hematol, Haifa, Israel
[3] Univ Milan, Fdn IRCCS Ca Granda, Div Hematol, I-20122 Milan, Italy
[4] Univ Modena & Reggio Emilia, Dept Surg Med Odontoiatr & Morphol Sci, Cellular Signaling Lab, I-41124 Modena, Italy
[5] Hadassah Univ Hosp, Dept Hematol, IL-91120 Jerusalem, Israel
[6] Hebrew Univ Jerusalem, Sch Med, IL-91010 Jerusalem, Israel
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 06期
关键词：
Monocytosis; Non-Hodgkin lymphoma; Peripheral T-cell lymphoma; Prognostic value; Overall survival; NON-HODGKINS-LYMPHOMA; UNSPECIFIED PTCL-U; ABSOLUTE MONOCYTE; LYMPHOPENIA; EXPRESSION; DIAGNOSIS; COUNT; MODEL; SCORE; SIGNATURES;
D O I：
10.1016/j.leukres.2013.01.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this retrospective study we evaluated the prognostic impact of peripheral blood monocytosis in patients with T-cell non Hodgkin lymphomas with "aggressive-typically nodal presentation". In this dataset monocytes >0.8 x 10(9)/L had a strong and statistically significant negative impact on overall survival (OS). In univariate analysis several parameters, including age >60 years, advanced stage, bone marrow involvement, ECOG PS > 1, high LDH level, monocytes >0.8 x 10(9)/L, hemoglobin < 120 g/L, albumin < 35 g/L) had a negative influence on outcome, but in multivariate analysis, monocytosis alone had a stronger association with poor OS. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：619 / 623
页数：5
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