Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female

被引:8
作者
Shoar, Zohreh [1 ]
Dunne, Christopher [1 ]
Yorns, William, Jr. [2 ]
De Luca, Francesco [1 ]
Rezvani, Geoffrey [1 ]
机构
[1] Drexel Univ, Coll Med, St Christophers Hosp Children, Sect Endocrinol & Diabet, Philadelphia, PA 19134 USA
[2] Drexel Univ, Coll Med, St Christophers Hosp Children, Neurol Sect, Philadelphia, PA 19134 USA
关键词
alpha coma; diabetes complications; diabetic ketoacidosis; cerebral hemorrhage; type 1 diabetes mellitus; C-REACTIVE PROTEIN; INTRAVASCULAR COAGULATION; MELLITUS; ASSOCIATION; INFARCTION; THROMBOSIS; PROGNOSIS; CHILDREN; ETIOLOGY; STROKE;
D O I
10.1515/jpem-2012-0321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background : Diabetic ketoacidosis (DKA) is one of the most common and harmful complications of type 1 diabetes in children. The neurologic morbidities, including seizure activity, motor/sensory deficit, and coma, can be seen secondary to cerebral edema, hemorrhage, or ischemia. Alpha-frequency is a normal 8-13 Hz physiologic electroencephalogram rhythm that is seen most prominently in the occipital region of awake people and is augmented by eye closure. In the comatose patient, alpha-rhythm is not usually seen. Alpha-frequency coma (AC) is a rare finding in comatose patients and is generally associated with a poor prognosis. Case report : We report an adolescent with severe DKA, intraparenchymal cerebral hemorrhage, and AC, who had a rapid resolution of the neurologic symptoms. Conclusions : Similar to other reported cases, our case suggests that the prognosis for patients with AC may not be always poor when it is associated with DKA.
引用
收藏
页码:561 / 564
页数:4
相关论文
共 33 条
[1]  
Atluru V L, 1986, Pediatr Neurol, V2, P167, DOI 10.1016/0887-8994(86)90011-1
[2]   ETIOLOGY AND PROGNOSIS OF ALPHA-COMA [J].
AUSTIN, EJ ;
WILKUS, RJ ;
LONGSTRETH, WT .
NEUROLOGY, 1988, 38 (05) :773-777
[3]   HEMORRHAGIC INFARCTION - RISK-FACTORS, CLINICAL AND TOMOGRAPHIC FEATURES, AND OUTCOME - A CASE-CONTROL STUDY [J].
BEGHI, E ;
BOGLIUN, G ;
CAVALETTI, G ;
SANGUINETI, I ;
TAGLIABUE, M ;
AGOSTONI, F ;
MACCHI, I .
ACTA NEUROLOGICA SCANDINAVICA, 1989, 80 (03) :226-231
[4]   DISSEMINATED INTRAVASCULAR COAGULATION AND SEVERE PERIPHERAL NEUROPATHY COMPLICATING KETOACIDOSIS IN A NEWLY-DIAGNOSED DIABETIC CHILD [J].
BONFANTI, R ;
BOGNETTI, E ;
MESCHI, F ;
MEDAGLINI, S ;
DANGELO, A ;
CHIUMELLO, G .
ACTA DIABETOLOGICA, 1994, 31 (03) :173-174
[5]   HYPERGLYCEMIA AND HEMORRHAGIC TRANSFORMATION OF CEREBRAL INFARCTS [J].
BRODERICK, JP ;
HAGEN, T ;
BROTT, T ;
TOMSICK, T .
STROKE, 1995, 26 (03) :484-487
[6]   Diabetic ketoacidosis promotes a prothrombotic state [J].
Carl, GF ;
Hoffman, WH ;
Passmore, GG ;
Truemper, EJ ;
Lightsey, AL ;
Cornwell, PE ;
Jonah, MH .
ENDOCRINE RESEARCH, 2003, 29 (01) :73-82
[7]   Diabetes mellitus - A hypercoagulable state [J].
Carr, ME .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2001, 15 (01) :44-54
[8]   POSSIBLE ROLE FOR INCREASED C4B-BINDING PROTEIN LEVEL IN ACQUIRED PROTEIN-S DEFICIENCY IN TYPE-I DIABETES [J].
CERIELLO, A ;
BARBANTI, M ;
GIUGLIANO, D ;
LEFEBVRE, P ;
QUATRARO, A ;
MARCHI, E .
DIABETES, 1990, 39 (04) :447-449
[9]  
Dalton RR, 2003, ANN CLIN LAB SCI, V33, P435
[10]   Simultaneous pulmonary and cerebral oedema, and multiple CNS infarctions as complications of diabetic ketoacidosis: a case report [J].
Dixon, AN ;
Jude, EB ;
Banerjee, AK ;
Bain, SC .
DIABETIC MEDICINE, 2006, 23 (05) :571-573