Spinal Cord Tumor Microenvironment

被引：6

作者：

Rauschenbach, Laurel ^{[1
,2
]}

机构：

[1] Univ Hosp Essen, Dept Neurosurg, Essen, Germany

[2] Univ Hosp Essen, German Canc Consortium DKTK Partner Site, West German Canc Ctr WTZ, DKFZ Div Translat Neurooncol, Essen, Germany

来源：

TUMOR MICROENVIRONMENTS IN ORGANS: FROM THE BRAIN TO THE SKIN - PT A | 2020年 / 1226卷

关键词：

Spinal cord; Central nervous system; Intramedullary; Tumor; Cancer; Astrocytoma; Ependymoma; Microenvironment; Blood-spinal cord barrier; Vascularization; Astrocytes; Neurons; Pericytes; Immune system; Extracellular matrix; GLIOMA-INFILTRATING MICROGLIA/MACROPHAGES; MESENCHYMAL STEM-CELLS; BLOOD-BRAIN-BARRIER; COSTIMULATORY MOLECULES; LYMPHOCYTE RATIO; MICROGLIAL CELLS; PROGENITOR CELLS; DENDRITIC CELLS; CANCER; EXPRESSION;

D O I：

10.1007/978-3-030-36214-0_8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intramedullary spinal cord tumors (IMSCT) are rare entities for which there currently exist no standardized treatment paradigms. Consequently, patients usually receive treatment modalities that were established for intracerebral tumors; these approaches, however, typically result in functional impairment, recurrent tumor growth, and short overall survival. There is a distinct lack of promising research efforts in this field, which raises questions about whether spinal cord tumor microenvironment (TME) might promote the development, progression, and treatment resistance of IMSCT. In this review, we aim to examine spinal cord biology, compare spinal cord and brain microenvironments, and discuss mutual interactions between IMSCT and TME. Manipulating these pathways may provide new treatment approaches for future patient groups.

引用

页码：97 / 109

页数：13

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