Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population

被引：8

作者：

Duan, Xianglong ^{[1
]}

Cao, Wei ^{[2
]}

Wang, Lijie ^{[3
]}

Liu, Sida ^{[1
]}

Liu, Zhao ^{[4
]}

Zhang, Bolun ^{[5
]}

Yang, Hua ^{[6
]}

Feng, Tian ^{[6
]}

Zhang, Jiayi ^{[7
]}

Zhang, Xiyang ^{[7
]}

Long, Yanbin ^{[1
]}

Jin, Tianbo ^{[6
,7
,8
]}

机构：

[1] Shaanxi Prov Peoples Hosp, Dept Gen Surg 2, Xian 710068, Peoples R China

[2] Shaanxi Prov Peoples Hosp, Dept Surg Oncol, Xian 710068, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Resp Med, Beijing 100853, Peoples R China

[4] Xian TB & Thorac Tumor Hosp, Xian Chest Hosp, Dept Surg, Xian 710100, Peoples R China

[5] Inner Mongolia Med Univ, Grad Sch, Hohhot 010030, Peoples R China

[6] Xian Tiangen Precis Med Inst, Xian 710075, Shaanxi, Peoples R China

[7] Northwest Univ, Sch Life Sci, Xian 710069, Peoples R China

[8] Xizang Minzu Univ, Sch Med, Key Lab Mol Mech & Intervent Res Plateau Dis Tibe, Xianyang 712082, Shaanxi, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 50期

基金：

中国国家自然科学基金;

关键词：

gastric cancer (GC); telomerase reverse transcriptase (TERT); single nucleotide polymorphisms (SNP); TELOMERASE REVERSE-TRANSCRIPTASE; MULTIPLE INDEPENDENT VARIANTS; GENOME-WIDE ASSOCIATION; PRENEOPLASTIC LESIONS; PROMOTER MUTATIONS; EXPRESSION; LENGTH; HTERT; LOCUS; POLYMORPHISMS;

D O I：

10.18632/oncotarget.13102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at Chr5p15.33, which is associated with multiple cancer types. In this study, we validated the association between TERT polymorphisms and gastric cancer (GC) risk with a case-control study in a Chinese Han population. A total of 302 GC patients and 300 control individuals were recruited. We identified three single nucleotide polymorphisms (SNPs) in TERT that were associated with GC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models after adjusting for age and gender to assess the association. The minor alleles of three SNPs were associated with increased GC risk inallelic model analysis. For two of the SNPs, rs10069690 and rs2853676,, the dominant and additive model frequencies were higher in GC cases compared to controls. Further haplotype analysis revealed a protective effect of haplotype "CG'' of the TERT gene, while the haplotype "TA" increased GC risk. Our results provide new evidence for the association between TERT and GC susceptibility in the Chinese Han population.

引用

页码：82727 / 82732

页数：6

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