Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population

被引：8

作者：

Duan, Xianglong ^{[1
]}

Cao, Wei ^{[2
]}

Wang, Lijie ^{[3
]}

Liu, Sida ^{[1
]}

Liu, Zhao ^{[4
]}

Zhang, Bolun ^{[5
]}

Yang, Hua ^{[6
]}

Feng, Tian ^{[6
]}

Zhang, Jiayi ^{[7
]}

Zhang, Xiyang ^{[7
]}

Long, Yanbin ^{[1
]}

Jin, Tianbo ^{[6
,7
,8
]}

机构：

[1] Shaanxi Prov Peoples Hosp, Dept Gen Surg 2, Xian 710068, Peoples R China

[2] Shaanxi Prov Peoples Hosp, Dept Surg Oncol, Xian 710068, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Resp Med, Beijing 100853, Peoples R China

[4] Xian TB & Thorac Tumor Hosp, Xian Chest Hosp, Dept Surg, Xian 710100, Peoples R China

[5] Inner Mongolia Med Univ, Grad Sch, Hohhot 010030, Peoples R China

[6] Xian Tiangen Precis Med Inst, Xian 710075, Shaanxi, Peoples R China

[7] Northwest Univ, Sch Life Sci, Xian 710069, Peoples R China

[8] Xizang Minzu Univ, Sch Med, Key Lab Mol Mech & Intervent Res Plateau Dis Tibe, Xianyang 712082, Shaanxi, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 50期

基金：

中国国家自然科学基金;

关键词：

gastric cancer (GC); telomerase reverse transcriptase (TERT); single nucleotide polymorphisms (SNP); TELOMERASE REVERSE-TRANSCRIPTASE; MULTIPLE INDEPENDENT VARIANTS; GENOME-WIDE ASSOCIATION; PRENEOPLASTIC LESIONS; PROMOTER MUTATIONS; EXPRESSION; LENGTH; HTERT; LOCUS; POLYMORPHISMS;

D O I：

10.18632/oncotarget.13102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomerase reverse transcriptase (TERT) is a gene within the cancer susceptibility region located at Chr5p15.33, which is associated with multiple cancer types. In this study, we validated the association between TERT polymorphisms and gastric cancer (GC) risk with a case-control study in a Chinese Han population. A total of 302 GC patients and 300 control individuals were recruited. We identified three single nucleotide polymorphisms (SNPs) in TERT that were associated with GC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models after adjusting for age and gender to assess the association. The minor alleles of three SNPs were associated with increased GC risk inallelic model analysis. For two of the SNPs, rs10069690 and rs2853676,, the dominant and additive model frequencies were higher in GC cases compared to controls. Further haplotype analysis revealed a protective effect of haplotype "CG'' of the TERT gene, while the haplotype "TA" increased GC risk. Our results provide new evidence for the association between TERT and GC susceptibility in the Chinese Han population.

引用

页码：82727 / 82732

页数：6

共 30 条

[1] Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer [J].

Bojesen, Stig E. ;

Pooley, Karen A. ;

Johnatty, Sharon E. ;

Beesley, Jonathan ;

Michailidou, Kyriaki ;

Tyrer, Jonathan P. ;

Edwards, Stacey L. ;

Pickett, Hilda A. ;

Shen, Howard C. ;

Smart, Chanel E. ;

Hillman, Kristine M. ;

Mai, Phuong L. ;

Lawrenson, Kate ;

Stutz, Michael D. ;

Lu, Yi ;

Karevan, Rod ;

Woods, Nicholas ;

Johnston, Rebecca L. ;

French, Juliet D. ;

Chen, Xiaoqing ;

Weischer, Maren ;

Nielsen, Sune F. ;

Maranian, Melanie J. ;

Ghoussaini, Maya ;

Ahmed, Shahana ;

Baynes, Caroline ;

Bolla, Manjeet K. ;

Wang, Qin ;

Dennis, Joe ;

McGuffog, Lesley ;

Barrowdale, Daniel ;

Lee, Andrew ;

Healey, Sue ;

Lush, Michael ;

Tessier, Daniel C. ;

Vincent, Daniel ;

Bacot, Francis ;

Vergote, Ignace ;

Lambrechts, Sandrina ;

Despierre, Evelyn ;

Risch, Harvey A. ;

Gonzalez-Neira, Anna ;

Rossing, Mary Anne ;

Pita, Guillermo ;

Doherty, Jennifer A. ;

Alvarez, Nuria ;

Larson, Melissa C. ;

Fridley, Brooke L. ;

Schoof, Nils ;

Chang-Claude, Jenny .

NATURE GENETICS, 2013, 45 (04) :371-384

[2] Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls [J].

Cao, Jin-Lin ;

Yuan, Ping ;

Abuduwufuer, Abudumailamu ;

Lv, Wang ;

Yang, Yun-Hai ;

Hu, Jian .

PLOS ONE, 2015, 10 (06)

[3] Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk [J].

Carvajal-Carmona, Luis G. ;

O'Mara, Tracy A. ;

Painter, Jodie N. ;

Lose, Felicity A. ;

Dennis, Joe ;

Michailidou, Kyriaki ;

Tyrer, Jonathan P. ;

Ahmed, Shahana ;

Ferguson, Kaltin ;

Healey, Catherine S. ;

Pooley, Karen ;

Beesley, Jonathan ;

Cheng, Timothy ;

Jones, Angela ;

Howarth, Kimberley ;

Martin, Lynn ;

Gorman, Maggie ;

Hodgson, Shirley ;

Wentzensen, Nicholas ;

Fasching, Peter A. ;

Hein, Alexander ;

Beckmann, Matthias W. ;

Renner, Stefan P. ;

Doerk, Thilo ;

Hillemanns, Peter ;

Duerst, Matthias ;

Runnebaum, Ingo ;

Lambrechts, Diether ;

Coenegrachts, Lieve ;

Schrauwen, Stefanie ;

Amant, Frederic ;

Winterhoff, Boris ;

Dowdy, Sean C. ;

Goode, Ellen L. ;

Teoman, Attila ;

Salvesen, Helga B. ;

Trovik, Jone ;

Njolstad, Tormund S. ;

Werner, Henrica M. J. ;

Scott, Rodney J. ;

Ashton, Katie ;

Proietto, Tony ;

Otton, Geoffrey ;

Wersaell, Ofra ;

Mints, Miriam ;

Tham, Emma ;

Hall, Per ;

Czene, Kamila ;

Liu, Jianjun ;

Li, Jingmei .

HUMAN GENETICS, 2015, 134 (02) :231-245

[4] Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations [J].

Du, Jiangbo ;

Xu, Yaochu ;

Dai, Juncheng ;

Ren, Chuanli ;

Zhu, Chen ;

Dai, Ningbin ;

Ma, Hongxia ;

Shi, Yongyong ;

Hu, Zhibin ;

Lin, Dongxin ;

Shen, Hongbing ;

Jin, Guangfu .

CARCINOGENESIS, 2013, 34 (11) :2539-2542

[5]

Duarte MC, 2011, BRAZ J MED BIOL RES, V44, P100, DOI 10.1590/S0100-879X2011000200003

[6] Telomerase activity in proximal and distal gastric neoplastic and preneoplastic lesions using immunohistochemical detection of hTERT [J].

Gulmann, C ;

Lantuejoul, S ;

Grace, A ;

Leader, M ;

Patchett, S ;

Kay, E .

DIGESTIVE AND LIVER DISEASE, 2005, 37 (06) :439-445

[7] A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer [J].

Haiman, Christopher A. ;

Chen, Gary K. ;

Vachon, Celine M. ;

Canzian, Federico ;

Dunning, Alison ;

Millikan, Robert C. ;

Wang, Xianshu ;

Ademuyiwa, Foluso ;

Ahmed, Shahana ;

Ambrosone, Christine B. ;

Baglietto, Laura ;

Balleine, Rosemary ;

Bandera, Elisa V. ;

Beckmann, Matthias W. ;

Berg, Christine D. ;

Bernstein, Leslie ;

Blomqvist, Carl ;

Blot, William J. ;

Brauch, Hiltrud ;

Buring, Julie E. ;

Carey, Lisa A. ;

Carpenter, Jane E. ;

Chang-Claude, Jenny ;

Chanock, Stephen J. ;

Chasman, Daniel I. ;

Clarke, Christine L. ;

Cox, Angela ;

Cross, Simon S. ;

Deming, Sandra L. ;

Diasio, Robert B. ;

Dimopoulos, Athanasios M. ;

Driver, W. Ryan ;

Duennebier, Thomas ;

Durcan, Lorraine ;

Eccles, Diana ;

Edlund, Christopher K. ;

Ekici, Arif B. ;

Fasching, Peter A. ;

Feigelson, Heather S. ;

Flesch-Janys, Dieter ;

Fostira, Florentia ;

Foersti, Asta ;

Fountzilas, George ;

Gerty, Susan M. ;

Giles, Graham G. ;

Godwin, Andrew K. ;

Goodfellow, Paul ;

Graham, Nikki ;

Greco, Dario ;

Hamann, Ute .

NATURE GENETICS, 2011, 43 (12) :1210-U61

[8] Surrogate tissue telomere length and cancer risk: Shorter or Longer? [J].

Hou, Lifang ;

Zhang, Xiao ;

Gawron, Andrew J. ;

Liu, Jie .

CANCER LETTERS, 2012, 319 (02) :130-135

[9] Highly Recurrent TERT Promoter Mutations in Human Melanoma [J].

Huang, Franklin W. ;

Hodis, Eran ;

Xu, Mary Jue ;

Kryukov, Gregory V. ;

Chin, Lynda ;

Garraway, Levi A. .

SCIENCE, 2013, 339 (6122) :957-959

[10] Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor [J].

Jin, Xun ;

Beck, Samuel ;

Sohn, Young-Woo ;

Kim, Jun-Kyum ;

Kim, Sung-Hak ;

Yin, Jinlong ;

Pian, Xumin ;

Kim, Sung-Chan ;

Choi, Yun-Jaie ;

Kim, Hyunggee .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2010, 42 (08) :574-582

← 1 2 3 →