Somatostatin receptors and regulation of cell proliferation

被引：41
作者：
Bousquet, C [1 ]
Guillermet, J [1 ]
Vernejoul, F [1 ]
Lahlou, H [1 ]
Buscail, L [1 ]
Susini, C [1 ]
机构：
[1] CHU Rangueil, INSERM, U531, IFR 31, F-31403 Toulouse 4, France
来源：
DIGESTIVE AND LIVER DISEASE | 2004年 / 36卷
关键词：
antioncogene; apoptosis; inhibition; proliferation; receptors; somatostatin; sst2;
D O I：
10.1016/j.dld.2003.11.007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Somatostatin is an inhibitory neuropeptide, which acts on various targets throughout the body to regulate a variety of physiological functions including inhibition of endocrine and exocrine secretions, modulation of neurotransmission, motor and cognitive functions, inhibition of intestinal motility, absorption of nutrients and ions, vascular contractility and inhibition of normal and tumour cell proliferation. It exerts its effects through interaction with five somatostatin receptors (sstl-sst5), which belong to the family of G-protein-coupled receptors with seven transmembrane spanning domains and are variably expressed in a variety of tumours such as gastroenteropancreatic tumours, pituitary tumours, and carcinoid tumours. This review covers the present knowledge regarding the molecular mechanisms involved in somatostatin antineoplastic activity. Evidence that sst2 receptor acts as a tumour suppressor is also discussed. (C) 2003 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：S2 / S7
页数：6
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