A Functional MicroRNA-155 Ortholog Encoded by the Oncogenic Marek's Disease Virus

被引：116

作者：

Zhao, Yuguang ^{[1
]}

Yao, Yongxiu ^{[1
]}

Xu, Hongtao ^{[1
]}

Lambeth, Luke ^{[1
]}

Smith, Lorraine P. ^{[1
]}

Kgosana, Lydia ^{[1
]}

Wang, Xiaowei ^{[2
]}

Nair, Venugopal ^{[1
]}

机构：

[1] Inst Anim Hlth, Div Microbiol, Viral Oncogenesis Grp, Compton RG20 7NN, Berks, England

[2] Washington Univ, Sch Med, Dept Radiat Oncol, St Louis, MO 63110 USA

来源：

JOURNAL OF VIROLOGY | 2009年 / 83卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

B-CELL LYMPHOMA; GENE-EXPRESSION; NONCODING RNA; DIFFERENTIATION; MIR-155; REPRESSION; PREDICTION; LINE;

D O I：

10.1128/JVI.01166-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis.

引用

页码：489 / 492

页数：4

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