Intravenous immunoglobulin in therapy of peripheral neuropathy

被引:8
|
作者
Gorshtein, A
Levy, Y [1 ]
机构
[1] Meir Hosp, Dept Internal Med E, Kefar Sava, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
intravenous immunoglobulin; peripheral neuropathy; Guillain-Barre syndrome; chronic inflammatory demyelinating polyneuropathy; multifocal motor neuropathy; diabetic amyotrophy; paraproteinemia; human immune deficiency virus; paraneoplastic neuropathy;
D O I
10.1385/CRIAI:29:3:271
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Peripheral neuropathy (PN) can be a manifestation of various neurological, infectious, metabolic, autoimmune, rheumatic, and malignant diseases. During the past decade, intravenous immunoglobulin (IVIg) has been increasingly used in the therapy of PN. Compared with other immunomodulatory therapies, IVIg has an excellent safety profile. IVIg is used today as a first-line therapy in the treatment of Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Some small studies and reports of clinical cases presented in this article found benefit from IVIg in treating PN associated with diabetes, paraproteinemia, HIV, multisystem rheumatic diseases, and paraneoplastic PN. No clear recommendations can be made relating the use of IVIg in these conditions. Prospective, randomized trials are required to clarify this issue.
引用
收藏
页码:271 / 279
页数:9
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