Oxidants, antioxidants and the current incurability of metastatic cancers

被引：260

作者：

Watson, Jim ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

OPEN BIOLOGY | 2013年 / 3卷

关键词：

cancer; reactive oxygen species; metastatic cancer; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-DEATH; THERAPEUTIC TARGET; INHIBITION; MYC; ROS; MECHANISMS; RESISTANCE; PACLITAXEL; MORTALITY;

D O I：

10.1098/rsob.120144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vast majority of all agents used to directly kill cancer cells (ionizing radiation, most chemotherapeutic agents and some targeted therapies) work through either directly or indirectly generating reactive oxygen species that block key steps in the cell cycle. As mesenchymal cancers evolve from their epithelial cell progenitors, they almost inevitably possess much-heightened amounts of antioxidants that effectively block otherwise highly effective oxidant therapies. Also key to better understanding is why and how the anti-diabetic drug metformin (the world's most prescribed pharmaceutical product) preferentially kills oxidant-deficient mesenchymal p53(-/-) cells. A much faster timetable should be adopted towards developing more new drugs effective against p53(-/-) cancers.

引用

页数：9

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