T cell costimulation by derivatives of benzoic acid

被引：14
作者：
Kinchington, D
Ng, T
Mathews, N
Tisdale, M
Devine, D
Ayuko, WO
机构：
[1] ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT,DEPT IMMUNOL,LONDON EC1A 7BE,ENGLAND
[2] ASTON UNIV,INST PHARMACEUT SCI,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND
来源：
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1997年 / 8卷 / 02期
关键词：
costimulation; HIV; immune dysregulation; immunodeficiency; immunomodulator; signal transduction;
D O I：
10.1177/095632029700800206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A number of analogues of benzoic acid were evaluated in a T cell costimulation assay. One compound, the sodium salt of 2-chloro-5-nitrobenzoic acid (CNBA-Na) was chosen for further study and was found to be a potent costimulator of anti-CD3-induced proliferation of both H9 lymphoblastoid cells (P<0.001) and human peripheral blood mononuclear cells (P=0.001) in a dose-dependent manner. The costimulatory effect of CNBA-Na on CD3-triggered DNA synthesis did not enhance human immunodeficiency virus replication in infected cells. Studies with blocking monoclonal antibodies against B7-1 or B7-2 indicated that the immunopotentiatory effect of CNBA-Na required a macromolecular interaction between CD28 (a costimulatory receptor on T cells) and its counter receptor B7 expressed on antigen-presenting cells. The discovery that this low molecular weight compound causes T cell proliferation highlights a potentially novel therapeutic approach to immunodeficiency diseases.
引用
收藏
页码：121 / 130
页数：10
相关论文
共 16 条
[1]  
AYUKO WO, 1991, THESIS ASTON U BIRMI
[2]   Activation of the IL-2 gene promoter by HTLV-I Tax involves induction of NF-AT complexes bound to the CD28-responsive element [J].
Good, LF ;
Maggirwar, SB ;
Sun, SC .
EMBO JOURNAL, 1996, 15 (14) :3744-3750
[3]   RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION [J].
HO, DD ;
NEUMANN, AU ;
PERELSON, AS ;
CHEN, W ;
LEONARD, JM ;
MARKOWITZ, M .
NATURE, 1995, 373 (6510) :123-126
[4]   THE B7 AND CD28 RECEPTOR FAMILIES [J].
JUNE, CH ;
BLUESTONE, JA ;
NADLER, LM ;
THOMPSON, CB .
IMMUNOLOGY TODAY, 1994, 15 (07) :321-331
[5]   THE EFFECT OF 1-CHLORO-2,4-DINITROBENZENE EXPOSURE ON ANTIGEN RECEPTOR (CD3)-STIMULATED TRANSMEMBRANE SIGNAL TRANSDUCTION IN PURIFIED SUBSETS OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES [J].
KAVANAGH, TJ ;
GROSSMANN, A ;
JINNEMAN, JC ;
KANNER, SB ;
WHITE, CC ;
EATON, DL ;
LEDBETTER, JA ;
RABINOVITCH, PS .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1993, 119 (01) :91-99
[6]   COMPARISON OF ANTIGEN CAPTURE ASSAYS AGAINST HIV-1 IN EVALUATING ANTIVIRAL COMPOUNDS [J].
KINCHINGTON, D ;
GALPIN, SA ;
OCONNOR, TJ ;
JEFFRIES, DJ ;
WILLIAMSON, JD .
AIDS, 1989, 3 (02) :101-104
[7]  
KINCHINGTON D, 1997, IN PRESS ANIMAL CELL
[8]   KINETICS OF GAG-SPECIFIC CYTOTOXIC T-LYMPHOCYTE RESPONSES DURING THE CLINICAL COURSE OF HIV-1 INFECTION - A LONGITUDINAL ANALYSIS OF RAPID PROGRESSORS AND LONG-TERM ASYMPTOMATICS [J].
KLEIN, MR ;
VANBAALEN, CA ;
HOLWERDA, AM ;
KERKHOFGARDE, SR ;
BENDE, RJ ;
KEET, IPM ;
EEFTINCKSCHATTENKERK, JKM ;
OSTERHAUS, ADME ;
SCHUITEMAKER, H ;
MIEDEMA, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04) :1365-1372
[9]   Antiviral effect and ex vivo CD4(+) T cell proliferation in HIV-positive patients as a result of CD28 costimulation [J].
Levine, BL ;
Mosca, JD ;
Riley, JL ;
Carroll, RG ;
Vahey, MT ;
Jagodzinski, LL ;
Wagner, KF ;
Mayers, DL ;
Burke, DS ;
Weislow, OS ;
StLouis, DC ;
June, CH .
SCIENCE, 1996, 272 (5270) :1939-1943
[10]   THE EFFECT OF CYTOKINES AND PHARMACOLOGICAL AGENTS ON CHRONIC HIV-INFECTION [J].
POLI, G ;
FAUCI, AS .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (02) :191-197
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