The Changing View of High-Grade Serous Ovarian Cancer

被引：131

作者：

Berns, Els M. J. J. ^{[1
,2
]}

Bowtell, David D. ^{[1
,3
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Genom & Genet Program, Melbourne, Vic 8006, Australia

[2] Erasmus MC Daniel Hoed Canc Ctr, Dept Med Oncol, Rotterdam, Netherlands

[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

来源：

CANCER RESEARCH | 2012年 / 72卷 / 11期

关键词：

FALLOPIAN-TUBE; PLATINUM RESISTANCE; GENE-EXPRESSION; CARCINOMA; MUTATIONS; CHEMOTHERAPY; CELL; CARCINOGENESIS; ACTIVATION; EVOLUTION;

D O I：

10.1158/0008-5472.CAN-11-3911

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The classification of epithelial ovarian cancer has been substantially revised, with an increased appreciation of the cellular origins and molecular aberrations of the different histotypes. Distinct patterns of signaling-pathway disruption are seen between and within histotypes. Large-scale genomic studies of high-grade serous cancer, the most common histotype, have identified novel molecular subtypes that are associated with distinct biology and clinical outcome. High-grade serous cancers are characterized by few driver point mutations but abundant DNA copy number aberrations. Inactivation of genes associated with DNA damage repair underlies responses to platinum and PARP inhibitors. Here we review these recent developments. Cancer Res; 72(11); 2701-4. (C)2012 AACR.

引用

页码：2701 / 2704

页数：4

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