Enhanced adhesion of osteoblastic cells on polystyrene films by independent control of surface topography and wettability

被引：30

作者：

Yang, Seung Yun ^{[1
,2
]}

Kim, Eung-Sam ^{[3
]}

Jeon, Gumhye ^{[1
,2
]}

Choi, Kwan Yong ^{[3
,4
]}

Kim, Jin Ron ^{[1
,2
]}

机构：

[1] Pohang Univ Sci & Technol, Natl Creat Res Ctr Block Copolymer Self Assembly, Dept Environm Sci & Engn, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Natl Creat Res Ctr Block Copolymer Self Assembly, Dept Chem Engn, Pohang 790784, South Korea

[3] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 790784, South Korea

[4] Pohang Univ Sci & Technol, Dept Life Sci, Div Mol & Life Sci, Pohang 790784, South Korea

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Osteoblast; Cell adhesion; Plasma surface modification; Polystyrene; Surface roughness; Bone remodeling; PLASMA TREATMENT; CHEMISTRY; GROWTH; BONE; SCAFFOLDS; RESPONSES; BEHAVIOR;

D O I：

10.1016/j.msec.2012.12.081

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We independently controlled surface topography and wettability of polystyrene (PS) films by CF4 and oxygen plasma treatments, respectively, to evaluate the adhesion and proliferation of human fetal osteoblastic (hFOB) cells on the films. Among the CF4 plasma-treated PS films with the average surface roughness ranging from 0.9 to 70 nm, the highest adhesion of hFOB cells was observed on a PS film with roughness of similar to 11 nm. When this film was additionally treated by oxygen plasma to provide a hydrophilic surface with a contact angle less than 10 degrees, the proliferation of bone-forming cell was further enhanced. Thus, the plasma-based independent modification of PS film into an optimum nanotexture for human osteoblast cells could be appplied to materials used in bone tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1689 / 1695

页数：7

共 38 条

[1] Controlling Cell Behavior Through the Design of Polymer Surfaces [J].