Synthesis and antibacterial evaluation of new sulfanyltetrazole derivatives bearing piperidine dithiocarbamate moiety

被引：11

作者：

Baghershiroudi, Mahrokh ^{[1
]}

Safa, Kazem D. ^{[1
]}

Adibkia, Khosro ^{[2
]}

Lotfipour, Farzaneh ^{[2
]}

机构：

[1] Univ Tabriz, Organosilicon Res Lab, Fac Chem, Tabriz 5166614766, Iran

[2] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 03期

关键词：

Antibacterial activity; carbodithioate; polarity; regioisomer; sulfanyltetrazole; ONE-POT SYNTHESIS; ANTITUBERCULAR AGENTS; ANTIFUNGAL; INHIBITORS; EFFICIENT; CATALYST;

D O I：

10.1080/00397911.2017.1401639

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new alkyl or aryl sulfanyltetrazole derivatives containing dithiocarbamate moiety (5a-6e) were synthesized. The structures of the compounds were characterized by IR, H-1 NMR, C-13 NMR spectra, and elemental analysis data. The present study examines the antibacterial potential of novel synthetic sulfanyltetrazole compounds against clinically important gram-positive and -negative strains. The results of screening showed that attachment of dithiocarbamate to sulfanyltetrazole derivatives results in enhancement of antibacterial activity. The compound 6d showed the best activity among the tested compounds. Also, the less polar 2,5-disubstituted sulfanyltetrazole regioisomers showed an increased antibacterial activity compared with the corresponding more polar regioisomers. [GRAPHICS] .

引用

页码：323 / 328

页数：6

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