Caenorhabditis elegans as a model system for human diseases

被引：89

作者：

Markaki, Maria ^{[1
]}

Tavernarakis, Nektarios ^{[1
,2
]}

机构：

[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion 70013, Crete, Greece

[2] Univ Crete, Sch Med, Dept Basic Sci, Iraklion 70013, Crete, Greece

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 63卷

基金：

欧洲研究理事会;

关键词：

ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CELL-DEATH; C-ELEGANS; TAU; AGGREGATION; GENETICS; SUSCEPTIBILITY; NEUROTOXICITY;

D O I：

10.1016/j.copbio.2019.12.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The nematode Caenorhabditis elegans offers unique advantages that enable a comprehensive delineation of the cellular and molecular mechanisms underlying devastating human pathologies such as stroke, ischemia and age-associated neurodegenerative disorders. Genetic models of human diseases that closely simulate several disease-related phenotypes have been established in the worm. These models allow the implementation of multidisciplinary approaches, in addition to large-scale genetic and pharmacological screenings, designed to elucidate the molecular mechanisms mediating pathogenesis and to identify targets and drugs for emergent therapeutic interventions. Such strategies have already provided valuable insights, highly relevant to human health and quality of life. This article considers the potential of C. elegans as a versatile platform for systematic dissection of the molecular basis of human disease, focusing on neurodegenerative disorders.

引用

页码：118 / 125

页数：8

共 61 条

[21] Genetic kidney diseases: Caenorhabditis elegans as model system [J].

Ganner, Athina ;

Neumann-Haefelin, Elke .

CELL AND TISSUE RESEARCH, 2017, 369 (01) :105-118

[22] Solvent exposures and parkinson disease risk in twins [J].

Goldman, Samuel M. ;

Quinlan, Patricia J. ;

Ross, G. Webster ;

Marras, Connie ;

Meng, Cheryl ;

Bhudhikanok, Grace S. ;

Comyns, Kathleen ;

Korell, Monica ;

Chade, Anabel R. ;

Kasten, Meike ;

Priestley, Benjamin ;

Chou, Kelvin L. ;

Fernandez, Hubert H. ;

Cambi, Franca ;

Langston, J. William ;

Tanner, Caroline M. .

ANNALS OF NEUROLOGY, 2012, 71 (06) :776-784

[23] Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans [J].

Griffin, Edward F. ;

Caldwell, Kim A. ;

Caldwell, Guy A. .

ACS CHEMICAL NEUROSCIENCE, 2017, 8 (12) :2596-2606

[24] MSUT2 is a determinant of susceptibility to tau neurotoxicity [J].

Guthrie, Chris R. ;

Greenup, Lynne ;

Leverenz, James B. ;

Kraemer, Brian C. .

HUMAN MOLECULAR GENETICS, 2011, 20 (10) :1989-1999

[25] SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans [J].

Guthrie, Chris R. ;

Schellenberg, Gerard D. ;

Kraemer, Brian C. .

HUMAN MOLECULAR GENETICS, 2009, 18 (10) :1825-1838

[26] Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model [J].

Hamamichi, Shusei ;

Rivas, Renee N. ;

Knight, Adam L. ;

Cao, Songsong ;

Caldwell, Kim A. ;

Caldwell, Guy A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (02) :728-733

[27] A Caenorhabditis elegans model of insulin resistance:: Altered macronutrient storage and dauer formation in an OGT-1 knockout [J].

Hanover, JA ;

Forsythe, ME ;

Hennessey, PT ;

Brodigan, TM ;

Love, DC ;

Ashwell, G ;

Krause, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (32) :11266-11271

[28] WormBase: a modern Model Organism Information Resource [J].

Harris, Todd W. ;

Arnaboldi, Valerio ;

Cain, Scott ;

Chan, Juancarlos ;

Chen, Wen J. ;

Cho, Jaehyoung ;

Davis, Paul ;

Gao, Sibyl ;

Grove, Christian A. ;

Kishore, Ranjana ;

Lee, Raymond Y. N. ;

Muller, Hans-Michael ;

Nakamura, Cecilia ;

Nuin, Paulo ;

Paulini, Michael ;

Raciti, Daniela ;

Rodgers, Faye H. ;

Russell, Matthew ;

Schindelman, Gary ;

Auken, Kimberly, V ;

Wang, Qinghua ;

Williams, Gary ;

Wright, Adam J. ;

Yook, Karen ;

Howe, Kevin L. ;

Schedl, Tim ;

Stein, Lincoln ;

Sternberg, Paul W. .

NUCLEIC ACIDS RESEARCH, 2020, 48 (D1) :D762-D767

[29] APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor is essential for viability [J].

Hornsten, Angela ;

Lieberthal, Jason ;

Fadia, Shruti ;

Malins, Richard ;

Ha, Lawrence ;

Xu, Xiaomeng ;

Daigle, Isabelle ;

Markowitz, Mindy ;

O'Connor, Gregory ;

Plasterk, Ronald ;

Li, Chris .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (06) :1971-1976

[30] XBP-1 Remodels Lipid Metabolism to Extend Longevity [J].

Imanikia, Soudabeh ;

Sheng, Ming ;

Castro, Cecilia ;

Griffin, Julian L. ;

Taylor, Rebecca C. .

CELL REPORTS, 2019, 28 (03) :581-+

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