Caenorhabditis elegans as a model system for human diseases

被引：89
作者：
Markaki, Maria [1 ]
Tavernarakis, Nektarios [1 ,2 ]
机构：
[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion 70013, Crete, Greece
[2] Univ Crete, Sch Med, Dept Basic Sci, Iraklion 70013, Crete, Greece
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2020年 / 63卷
基金：
欧洲研究理事会;
关键词：
ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CELL-DEATH; C-ELEGANS; TAU; AGGREGATION; GENETICS; SUSCEPTIBILITY; NEUROTOXICITY;
D O I：
10.1016/j.copbio.2019.12.011
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The nematode Caenorhabditis elegans offers unique advantages that enable a comprehensive delineation of the cellular and molecular mechanisms underlying devastating human pathologies such as stroke, ischemia and age-associated neurodegenerative disorders. Genetic models of human diseases that closely simulate several disease-related phenotypes have been established in the worm. These models allow the implementation of multidisciplinary approaches, in addition to large-scale genetic and pharmacological screenings, designed to elucidate the molecular mechanisms mediating pathogenesis and to identify targets and drugs for emergent therapeutic interventions. Such strategies have already provided valuable insights, highly relevant to human health and quality of life. This article considers the potential of C. elegans as a versatile platform for systematic dissection of the molecular basis of human disease, focusing on neurodegenerative disorders.
引用
收藏
页码：118 / 125
页数：8
相关论文
共 61 条
[1]   Caenorhabditis elegans as a model system for studying the nuclear lamina and laminopathic diseases [J].
Bank, Erin M. ;
Gruenbaum, Yosef .
NUCLEUS, 2011, 2 (05) :350-357
[2]   Genetic insights in Alzheimer's disease [J].
Bettens, Karolien ;
Sleegers, Kristel ;
Van Broeckhoven, Christine .
LANCET NEUROLOGY, 2013, 12 (01) :92-104
[3]   PolyQ disease: misfiring of a developmental cell death program? [J].
Blum, Elyse S. ;
Schwendeman, Andrew R. ;
Shaham, Shai .
TRENDS IN CELL BIOLOGY, 2013, 23 (04) :168-174
[4]   A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau [J].
Brandt, Roland ;
Gergou, Aikaterini ;
Wacker, Irene ;
Fath, Thomas ;
Hutter, Harald .
NEUROBIOLOGY OF AGING, 2009, 30 (01) :22-33
[5]  
BRENNER S, 1974, GENETICS, V77, P71
[6]   Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model [J].
Brignull, Heather R. ;
Moore, Finola E. ;
Tang, Stephanie J. ;
Morimoto, Richard I. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (29) :7597-7606
[7]   CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans [J].
Brunquell, Jessica ;
Raynes, Rachel ;
Bowers, Philip ;
Morris, Stephanie ;
Snyder, Alana ;
Lugano, Doreen ;
Deonarine, Andrew ;
Westerheide, Sandy D. .
AGING CELL, 2018, 17 (05)
[8]   Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease [J].
Buettner, Sabrina ;
Habernig, Lukas ;
Broeskamp, Filomena ;
Ruli, Doris ;
Voegtle, F. Nora ;
Vlachos, Manolis ;
Macchi, Francesca ;
Kuettner, Victoria ;
Carmona-Gutierrez, Didac ;
Eisenberg, Tobias ;
Ring, Julia ;
Markaki, Maria ;
Taskin, Asli Aras ;
Benke, Stefan ;
Ruckenstuhl, Christoph ;
Braun, Ralf ;
Van den Haute, Chris ;
Bammens, Tine ;
van der Perren, Anke ;
Froehlich, Kai-Uwe ;
Winderickx, Joris ;
Kroemer, Guido ;
Baekelandt, Veerle ;
Tavernarakis, Nektarios ;
Kovacs, Gabor G. ;
Dengjel, Joern ;
Meisinger, Chris ;
Sigrist, Stephan J. ;
Madeo, Frank .
EMBO JOURNAL, 2013, 32 (23) :3041-3054
[9]   Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].
不详 .
SCIENCE, 1998, 282 (5396) :2012-2018
[10]   Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans [J].
Cao, SS ;
Gelwix, CC ;
Caldwell, KA ;
Caldwell, GA .
JOURNAL OF NEUROSCIENCE, 2005, 25 (15) :3801-3812
1234567