In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum

被引：14

作者：

Joanny, Fanny ^{[1
,2
]}

Held, Jana ^{[1
,2
]}

Mordmueller, Benjamin ^{[1
,2
]}

机构：

[1] Univ Tubingen, Inst Tropenmed, Tubingen, Germany

[2] Ctr Rech Med Lambarene CERMEL, Lambarene, Gabon

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 11期

关键词：

RESISTANCE; TOXICITY; EXPOSURE; GROWTH; DRUGS;

D O I：

10.1128/AAC.00709-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs against P. falciparum.

引用

页码：5982 / 5985

页数：4

共 23 条

[11] Haugland R.P., 2005, HDB GUIDE FLUORESCEN, V10th
[12] In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon
Held, Jana
Soomro, Shahid A.
Kremsner, Peter G.
Jansen, F. Herwig
Mordmueller, Benjamin
[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (05) : 485 - 488
[13] In Vitro Activity of Mirincamycin (U24729A) against Plasmodium falciparum Isolates from Gabon
Held, Jana
Westerman, Richard
Kremsner, Peter G.
Mordmueller, Benjamin
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (01) : 540 - 542
[14] INHIBITION OF INVITRO GROWTH OF PLASMODIUM-FALCIPARUM BY A BRIEF EXPOSURE TO THE CATIONIC RHODAMINE DYES
IZUMO, A
TANABE, K
[J]. ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1986, 80 (03): : 299 - 305
[15] LOCALIZATION OF MITOCHONDRIA IN LIVING CELLS WITH RHODAMINE-123
JOHNSON, LV
WALSH, ML
CHEN, LB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (02): : 990 - 994
[16] DIOC6 STAINING REVEALS ORGANELLE STRUCTURE AND DYNAMICS IN LIVING YEAST-CELLS
KONING, AJ
LUM, PY
WILLIAMS, JM
WRIGHT, R
[J]. CELL MOTILITY AND THE CYTOSKELETON, 1993, 25 (02): : 111 - 128
[17] Eosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum
Massimine, Kristen M.
McIntosh, Michael T.
Doan, Lanxuan T.
Atreya, Chloe E.
Gromer, Stephan
Sirawaraporn, Worachart
Elliott, David A.
Joiner, Keith A.
Schirmer, R. Heiner
Anderson, Karen S.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) : 3132 - 3141
[18] Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing
Noedl, H
Bronnert, J
Yingyuen, K
Herwig, BA
Attlmayr, B
Kollaritsch, H
Fukuda, M
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) : 3575 - 3577
[19] Pournelle G. H., 1953, Journal of Mammalogy, V34, P133, DOI 10.1890/0012-9658(2002)083[1421:SDEOLC]2.0.CO
[20] 2

← 1 2 3 →