The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells

被引：14
|
作者：
Juzyszyn, Z. [1 ]
Czerny, B. [2 ]
Pawlik, A. [3 ]
Drozdzik, M. [1 ]
机构：
[1] Pomeranian Med Univ, Dept Expt & Clin Pharmacol, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Drug Toxicol & Pharmacoecon, PL-70111 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Pharmacokinet & Therapeut Drug Monitoring, PL-70111 Szczecin, Poland
来源：
PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 09期
关键词：
artichoke extract; antioxidants; ROS; HUVECs;
D O I：
10.1002/ptr.2385
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of an artichoke extract on induced reactive oxygen species (ROS) generation in cultured human umbilical endothelial cells (HUVECs) and its reductive properties were evaluated. Preincubation of HUVEC cells with the artichoke extract at concentrations of 25-100 mu g/mL for 24 h abolished ROS generation induced by LPS and oxyLDL as evaluated by the fluorescence intensity of 2',7'-dichlorofluorescein (DCF). Potent, concentration-dependent reductive properties of the artichoke extract were demonstrated by the reduction kinetics of cytochrome c in reference to ascorbate were also revealed. The results of the present study the warrant application of artichoke extracts as endothelium protecting agents. Copyright (c) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：1159 / 1161
页数：3
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